01547nam a2200289 a 450000100080000000500110000800800410001910000180006024501980007826001920027652005040046865000120097265000200098465000160100465300260102065300210104665300200106770000150108770000130110270000180111570000140113370000210114770000230116870000230119170000230121470000200123721597402023-12-15       2023    bl uuuu     u00u1 u    #d1 aYUYAMA, K. T.  aAntiprotozoal potential of the alkaloids isolated from the Amazon plant Malouetia tamaquarina (Apocynaceae) and its endophytes against Neglected Tropical Diseases (NTDs).h[electronic resource]  aIn: BRAZILIAN CONFERENCE ON NATURAL PRODUCT (BCNP), 9.; MEETING ON MICROMOLECULAR EVOLUTION, SYSTEMATICS AND ECOLOGY (RESEM), 35., 2023, Salvador. Proceedings [...] Campinas: Galoác2023  aExtracts of Malouetia tamaquarina and its endophytes presented antiprotozoal potential. Novel alkaloids (1 and 2) isolated from the bark of M. tamaquarina showed significant activities against Trypanosoma brucei rhodesiense (IC 50 of 20.4 and 2.3 ug/mL) and Plasmodium falciparum (IC 50 of 7.5 and 0.62 ug/mL) respectively. Also, from the endophytic fungus Cosmospora sp. (MT30), two fatty acids and colletorin B were isolated, and the evaluation of their biological activities is still in progress.  aMalaria  aTrypanosomiasis  aApocynaceae  aMalouetia tamaquarina  aNatural products  aProduto natural1 aMACEDO, C.1 aMELO, W.1 aGRUNDMANN, C.1 aSILVA, M.1 aAGUIAR, J. P. L.1 aCASTELLO, A. C. D.1 aFERREIRA, L. L. G.1 aANDRICOPULO, A. D.1 aSILVA, G. F. da