02071naa a2200325 a 450000100080000000500110000800800410001902400520006010000200011224501780013226000090031052010280031965000200134765000190136765300180138665300190140465300220142365300400144565300110148570000230149670000170151970000210153670000260155770000220158370000210160570000210162670000230164770000170167077300580168721572302023-10-16       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.3389/fphar.2023.11766292DOI1 aCHURA, S. S. D.  aRed sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial designbcytotoxicity and cellular reactive oxygen species levels.h[electronic resource]  c2023  aAmazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Croton cajucara Benth., contains metabolites characterized by antioxidant and anti-inflammatory activities. Nanostructured lipid carriers (NLC) are an advantageous alternative for the effective delivery of drugs because they can solubilize lipophilic actives and reduce their cytotoxicity. This study aimed to optimize the synthesis of RSO-loaded nanostructured lipid carriers (NLC-RSO) using a 23 factorial design and investigate their antioxidant and cytotoxic effects. The red sacaca essential oil (RSO) metabolite profile was characterized using gas chromatography coupled with a mass spectrometer (GC-MS), identifying 33 metabolites, with linalool and 7-hydroxy-calamenene as the major ones, as reported in the literature.  aCroton cajucara  aNanotechnology  aAmazon plants  aNanotecnologia  aPlant metabolites  aRotational central composite design  aSacaca1 aMEMÓRIA, K. A. S.1 aLOPES, A. T.1 aPELISSARI, F. M.1 aSILVEIRA, J. V. W. da1 aBEZERRA, J. de A.1 aCHAVES, F. C. M.1 aRODRIGUES, A. P.1 aFARIA, J. A. Q. A.1 aCARNEIRO, G.  tFrontiers in Pharmacologygv. 14, art. 1176629, 2023.