02660naa a2200325 a 450000100080000000500110000800800410001902400550006010000180011524501770013326000090031052016670031965000170198665000100200365000120201365000120202565000120203765000100204965300250205965300270208470000180211170000230212970000210215270000220217370000200219570000220221570000200223770000220225777300550227921551862023-09-02       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.foodres.2023.1132522DOI1 aLÚCIO, H. G.  aDry heat whole Sorghum BRS 305 flour modulate satiety and improves antioxidant response in brain of Wistar rats fed with high-fat high-fructose diet.h[electronic resource]  c2023  aSorghum BRS 305 (Sorghum bicolor L. Moench) is a cereal with high tannins and anthocyanins content and keep better the resistant starch when submitted to dry heat treatment. Our objective was to investigate the effects of BRS 305 dry heat treatment whole sorghum flour on satiety and antioxidant response in brain and adipose tissue of Wistar rats fed with a high fat high fructose diet (HFHF). Male Wistar rats were divided in two groups: control (n = 8) and HFHF (n = 16) for eight weeks. After, animals of HFHF group were divided: HFHF (n = 8) and HFHF + BRS 305 sorghum whole flour (n = 8), for 10 weeks. Sorghum consumption reduced gene expression of leptin, resistin, and endocannabinoid receptor 1 type (CB1) in adipose and brain tissues compared to HFHF group. In brain, sorghum consumption also promotes reduction in neuropeptide Y (NPY) gene expression. BRS305 sorghum consumption improved gene expression of sirtuin-1 (SIRT1) in adipose tissue, and in the brain increased heat shock protein 72 (HSP72), erythroid-derived nuclear factor 2 (NRF2), peroxisome proliferator-activated receptor alpha (PPARα), superoxide dismutase (SOD) and catalase activity compared to HFHF. In silico analysis showed interaction with PPARα, CB1, and leptin receptors. Advanced glycation end products (AGEs) concentrations in group HFHF + sorghum did not differ from HFHF group. Advanced glycation end products receptors (RAGEs) concentrations did not differ among experimental groups. Then, BRS 305 sorghum submitted to dry treatment was able to modulate gene expression of markers related to satiety and improve antioxidant capacity of rats fed with HFHF diet.  aAntioxidante  aDieta  aFarinha  aFrutose  aGordura  aSorgo  a3-desoxiantocianinas  aAtividade antioxidante1 aGRANCIERI, M.1 aMARTINEZ, O. D. M.1 aTOLEDO, R. C. L.1 aMENEZES, C. B. de1 aCOSTA, N. M. B.1 aQUEIROZ, V. A. V.1 aSILVA, B. P. da1 aMARTINO, H. S. D.  tFood Research Internationalgv. 173, 113252, 2023.