02922naa a2200541 a 450000100080000000500110000800800410001902200140006002400520007410000190012624501570014526000090030252013070031165000190161865000170163765000180165465000180167265000220169065000170171265000140172965000180174365000200176165300230178165300180180465300170182265300270183965300280186665300220189465300160191665300190193265300340195165300290198565300290201470000200204370000150206370000160207870000270209470000190212170000220214070000190216270000180218170000220219970000200222170000230224170000270226470000190229177300700231021550322023-11-16       2022    bl uuuu     u00u1 u    #d  a1878-81817 ahttps://doi.org/10.1016/j.bcab.2021.1022472DOI1 aBEZERRA, J. N.  aChemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC.h[electronic resource]  c2022  aChagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries.  aChagas disease  aCytotoxicity  aPublic health  aVegetable oil  aDoença de Chagas  aLeishmaniose  aMyrtaceae  aÓleo Vegetal  aSaúde Pública  aAnti kinetoplastid  aAntiparasitic  aCitotóxicos  aDoenças parasitárias  aEfeito antiparasitário  aParasitic disease  aPathologies  aPhytochemistry  aPsidium brownianum Mart ex DC  aTerapêutica alternativa  aTherapeutic alternatives1 aGOMEZ, M. C. V.1 aROLÓN, M.1 aCORONEL, C.1 aALMEIDA-BEZERRA, J. W.1 aFIDELIS, K. R.1 aMENEZES, S. A. de1 aCRUZ, R. P. da1 aDUARTE, A. E.1 aRIBEIRO, P. R. V.1 aBRITO, E. S. de1 aCOUTINHO, H. D. M.1 aMORAIS-BRAGA, M. F. B.1 aBEZERRA, C. F.  tBiocatalysis and Agricultural Biotechnologygv. 39, 102247, 2022.