02227naa a2200325 a 450000100080000000500110000800800410001902400520006010000160011224501440012826000090027252012510028165000160153265000210154865000190156965000200158865000200160865300180162870000190164670000210166570000190168670000200170570000170172570000220174270000190176470000180178370000230180170000190182477300580184321530302023-11-16       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s10499-023-01103-w2DOI1 aCARDOSO, L.  aLippia sidoides essential oil (Verbenaceae) improves infammatory response and histological condition in Danio rerio.h[electronic resource]  c2023  aThis study evaluated the efect of Lippia sidoides essential oil (LSEO), at a concentration of 0.25%, on the infammatory response and histological parameters in Danio rerio zebrafsh. Three hundred and ffteen fsh were equally distributed into 21 aquaria and divided into three groups with three replicates (negative control (NC), diet containing grain alcohol (GA) only, and LSEO?diet with Lippia sidoides). After 15 days, the animals were anesthetized, and the infammatory process was induced as follows: part of the fsh did not receive intraperitoneal injection (IP) negative control (NC); part of them received IP containing 0.65% saline solution (S) (NCS, GAS, and LSEOS); and another part received IP containing tumor (Ehrlich ascitic carcinoma) (T) (NCT, GAT, and LSEOT). After 6 h, the exudate was collected, and the histological analysis was performed. There was an increase in the number of basophils and monocytes in LSEOT, as well as an improvement in the histological conditions in all organs of the fsh in this group, suggesting a possible efect of essential oil on fsh defense mechanisms. Therefore, using LSEO at a concentration of 0.25% seems to be benefcial to the health of D. rerio subjected to IP with Ehrlich ascitic carcinoma.  aAquaculture  aMedicinal plants  aPhotochemistry  aLippia Sidoides  aÓleo Essencial  aEssential oil1 aOWATARI, M. S.1 aCHAVES, F. C. M.1 aFURTADO, W. E.1 aHONORATO, L. A.1 aAGNES, J. P.1 aSANTOS, D. C. dos1 aPEDROSA, R. C.1 aFONTES, S. T.1 aMOURIÑO, J. L. P.1 aMARTINS, M. L.  tAquaculture Internationalgv. 31, p. 2665-2685, 2023.