01754naa a2200253 a 450000100080000000500110000800800410001902400400006010000160010024501760011626000090029252009450030165000150124665000210126170000190128270000220130170000190132370000230134270000230136570000190138870000110140770000250141877300570144321514952023-03-24       2023    bl uuuu     u00u1 u    #d7 adoi.org/10.1002/cbdv.2022007602DOI1 aRUAS, N. R.  aInhibition of a-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking.h[electronic resource]  c2023  aThis study aimed to quantify verbascoside (VEB), perform molecular docking studies of VEB with the α-glucosidase (GL) of Bacillus stearothermophilus, and evaluate the inhibition of the enzyme by L. dulcis preparations. The substrate concentration and presence of reduced glutathione were evaluated for their effect on the in vitro inhibition of the GL enzyme. Assays were also performed in the presence and absence of simulated gastric fluid. The antidiabetic fractions 2 and 3 were the most inhibited GL, but their activity were significantly decreased in the presence of gastric fluid. Chromatographic analyses confirmed the predominant presence of VEB in the samples. The samples had VEB concentrations between 49.9 and 243.5 mg/g. Simulation of the molecular docking of VEB were consistent with its GL-inhibitory activity. It can conclude that the crude ethanol extract and fractions show inhibitory activity against the GL enzyme.  aCapim Doce  aPlanta Medicinal1 aPEREIRA, A. C.1 aPEREIRA, L. L. S.1 aGERMANO, C. M.1 aCUNHA, E. F. F. da1 aCARVALHO, A. A. de1 aLAMEIRA, O. A.1 aPINTO.1 aBERTOLUCCI, S. K. V.  tChemistry and Biodiversitygv. 20, e202200760, 2023.