01318naa a2200289 a 450000100080000000500110000800800410001902400480006010000180010824501600012626000090028652004080029565300290070365300190073265300210075165300300077265300170080270000210081970000200084070000150086070000210087570000210089670000200091770000130093770000210095077300570097121504662023-06-01       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1002/cbdv.2022006892DOI1 aGARCIA, A. R.  aAntileishmanial screening, cytotoxicity, and chemical composition of essential oilsba special focus on Piper callosumessential oil.h[electronic resource]  c2023  aIn the present study, we screened a panel of fourteen EO for their chemical composition and in vitro antileishmanial activity agaisnt L. amazonensis, the etiological agent of tegumentary leishmaniasis. Cytotoxicity was also evaluated against different mammalian cells to provide initial evidence of their safety. In addition, the mode of action of Piper callosum(the most effective EO) was investigated.  aAntileishmanial activity  aDrug screening  aDrug selectivity  aTegumentary leishmaniasis  aVolatileoils1 aAMARAL, A. C. F.1 aMARIA, A. C. B.1 aPAZ, M. M.1 aAMORIM, M. M. B.1 aCHAVES, F. C. M.1 aVERMELHO, A. B.1 aNICO, D.1 aRODRIGUES, I. A.  tChemistry and Biodiversitygv. 20, e202200689, 2023.