02488naa a2200289 a 450000100080000000500110000800800410001902200140006002400520007410000280012624501950015426000090034952015120035865000230187065000140189365000170190765000230192465000240194765000180197165000230198965300150201265300360202770000190206370000250208270000210210777300700212821495452022-12-13       2022    bl uuuu     u00u1 u    #d  a1614-74997 ahttps://doi.org/10.1007/s11356-022-24252-62DOI1 aCÔRTES, M. V. de C. B.  aSustainable production of biopesticides for common bean root rot control within the biorefinery approachba Technology Readiness Level 3 experimental proof of concept.h[electronic resource]  c2022  aBiopesticides are recognized as an efficient alternative to synthetic pesticides for pest and disease crop management. However, their commercial production processes use grains, generating large amounts of organic waste, even when agriculture waste or byproducts are the feedstock of choice. Frequently, these organic wastes are rich in nutrients that, after adequate treatment, can be used as nitrogen and carbohydrate sources for secondary metabolite production produced by microorganisms during submerged fermentation. In this sense, this study aimed to prove the concept that biopesticides could be produced under a full biorefinery process, using the entire biomass of an underexplored agroindustrial waste-damaged bean-as the main feedstock. A combination of sequential processes, including solid state fermentation, hydrolysis, and submerged fermentation, were designed for the production of two biopesticides (conventional?fungal conidia and second-generation secondary metabolite-cerulenin) from a high potential biological control agent strain Sarocladium oryzae BRM 59907. The combined processes, using damaged common bean grain as the main feedstock, provided biopesticides and organic fertilizer production that successfully controlled common bean root rot disease. This work proved to be possible the biopesticide production using a full biorefinery concept, inside the same productive chain, contributing to a sustainable environment and economy, together with animal and human health safety.  aBiological control  aCerulenin  aFermentation  aSarocladium oryzae  aControle Biológico  aFermentação  aRhizoctonia Solani  aBiocontrol  aNutrient-rich waste hydrolysate1 aBARRETO, M. S.1 aSILVA-LOBO, V. L. da1 aFREIRE, D. M. G.  tEnvironmental Science and Pollution Research International, 2022.