02375naa a2200301 a 450000100080000000500110000800800410001902400540006010000210011424501770013526000090031252014730032165000170179465000160181165000230182765000100185065000120186065000100187265300240188265300150190665300160192170000170193770000180195470000130197270000190198570000210200477300480202521481212022-12-12       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.nutres.2022.10.0052DOI1 aVEREDIANO, T. A.  aBlack corn (Zea mays L.) flour has the potential to improve the gut microbiota composition and goblet cell proliferation in mice fed a high-fat diet.h[electronic resource]  c2022  aHigh-fat diets are associated with intestinal dysbiosis and leaky gut leading to intestinal inflammation. Bioactive components, including phenolic compounds, isolated or in their original food matrix, have alleviated intestinal impairments promoted by a high-fat diet. Black corn (Zea mays L.) is a colored corn in which anthocyanins are the most abundant bioactive compound. Thus, we hypothesized that black corn flour has preventive effects on intestinal health in mice fed a high-fat diet. To study this, thirty C57BL/6 mice were randomly divided into three experimental groups receiving the following diets for eight weeks: NC: normal control (fed a normal diet); HF: high-fat (fed a high-fat diet: 60% of calories from fat); HFC: high-fat corn (fed a high-fat diet added with 20% of black corn whole flour). The cecal microbiota analyzed by 16S rRNA sequencing showed that black corn flour intake increased the relative abundance of Ruminococcus, Roseburia, and Prevotellaceae_UCG-001, and decreased Bacteroides and Faecalibaculum. No difference was observed in the cecal short-chain fatty acids and fecal pH among the experimental groups (p&gt0.05). Further, the consumption of black corn flour improved the cecal morphology by increasing the number of goblet cells but with no difference in the crypt depth and width. These findings suggest that black corn flour as a source of anthocyanins could have preventive effects on gut dysbiosis due to a high-fat diet.  aÁcido Graxo  aAntocianina  aComposto Fenólico  aDieta  aFarinha  aMilho  aBarreira intestinal  aMicrobiota  aMilho preto1 aSANT'ANA, C.1 aGRANCIERI, M.1 aTAKO, E.1 aPAES, M. C. D.1 aMARTIN, H. S. D.  tNutrition Researchgv. 108, p. 60-72, 2022.