02720naa a2200409 a 450000100080000000500110000800800410001902400520006010000240011224501370013626000090027352014920028265000240177465000230179865000120182165000150183365000150184865000140186365300270187765300090190465300240191365300350193765300130197265300260198565300170201165300280202870000200205670000170207670000200209370000220211370000180213570000220215370000210217570000220219670000300221877300620224821463032023-01-16       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.crfs.2022.02.0012DOI1 aLOUBET FILHO, P. S.  aGut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling.h[electronic resource]  c2022  aJabuticaba is a Brazilian berry known for its therapeutic potential against cancer, obesity, insulin resistance (IR), and others. It is a natural source of bioactive compounds, leading to better glucose metabolism, and attenuating obesity and IR through the reduction of pro-inflammatory status. The present study aimed to observe the prebiotic effect of freeze-dried jabuticaba peel (J) consumption on gut bacteria profile and describe its effects on IR derived from the lipopolysaccharides/Toll-like receptor-4 inflammatory pathway. Jabuticaba peel was chemically characterized, and its bioactive compounds were quantified. Twenty-four C57BL/6 mice were feed with a control diet (n = 6), control diet + J (n = 6), high-fat diet (HF) (n = 6), and HF + J (n = 6) for thirteen weeks. Gut bacteriota (16s RNA sequencing), glucose metabolism (fasting glucose and insulin, OGTT, ITT, HOMA-IR, and β, QUICKI), and inflammatory status (serum lipopolysaccharide, and protein expression) were assessed. The main bioactive compounds found in J were dietary fiber, and anthocyanins, and its consumption along with a healthy diet reduced the abundance of Firmicutes and Actinobacteriota phyla (p &lt 0.01), increased the Muribaculaceae and Lachnospiraceae families, and Faecalicatena genus (p &lt 0.05). The correlation test indicates a negative correlation between the Muribaculaceae and glucose metabolism. Jabuticaba peel is a nutritive source of bioactive compounds with prebiotic effects.  aBioactive compounds  aInsulin resistance  aObesity  aPrebiotics  aJabuticaba  aObesidade  aBactérias intestinais  aBaga  aCompostos bioativos  aConsumo de casca de jabuticaba  aDisbiose  aMicrobiota intestinal  aPrebióticos  aResistência a insulina1 aBASEGGIO, A. M.1 aVUOLO, M. R.1 aREGUENGO, L. M.1 aBIASOTO, A. C. T.1 aCORREA, L. C.1 aBOGUSZ JUNIOR, s.1 aCAGNON, V. H. A.1 aCAZARIN, C. B. B.1 aMARÓSTICA JÚNIOR, M. R.  tCurrent Research in Food Sciencegv. 5, p. 382-391, 2022.