02626naa a2200289 a 450000100080000000500110000800800410001902400460006010000280010624502050013426000090033952016870034865300220203565300160205765300210207365300190209465300180211370000230213170000180215470000210217270000200219370000230221370000210223670000190225770000180227677300420229421461462022-11-04       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.3390/biom120912082DOI1 aBATALHA, A. D. de S. J.  aTherapeutic potential of leaves from Fridericia chica (Bonpl.) L. G. Lohmannbbotanical aspects, phytochemical and biological, anti-Inflammatory, antioxidant and healing action.h[electronic resource]  c2022  aPlants of the species Fridericia chica (Bonpl.) L. G. Lohmann (Bignoniaceae), which are widely distributed in Brazil and named crajiru in the state of Amazonas, are known in folk medicine as a traditional medicine in the form of a tea for the treatment of intestinal colic, diarrhea, and anemia, among other diseases. The chemical analysis of extracts of the leaves has identified phenolic compounds, a class of secondary metabolites that provide defense for plants and benefits to the health of humans. Several studies have shown the therapeutic efficacy of F. chica extracts, with antitumor, antiviral, wound healing, anti-inflammatory, and antioxidant activities being among the therapeutic applications already proven. The healing action of F. chica leaf extract has been demonstrated in several experimental models, and shows the ability to favor the proliferation of fibroblasts, which is essential for tissue repair. The anti-inflammatory activity of F. chica has been clearly demonstrated by several authors, who suggest that it is related to the presence of 3-deoxyanthocyanidins, which is capable of inhibiting pro-inflammatory pathways such as the kappa B (NF-kB) nuclear transcription factor pathway. Another important effect attributed to this species is the antioxidant effect, attributed to phenolic compounds interrupting chain reactions caused by free radicals and donating hydrogen atoms or electrons. In conclusion, the species Fridericia chica has great therapeutic potential, which is detailed in this paper with the objective of encouraging new research and promoting the sum of efforts for the inclusion of herbal medicines in health systems around the world.  aAnti-inflammatory  aAntioxidant  aFridericia chica  aPhytochemistry  aWound healing1 aSOUZA, D. C. de M.1 aUBIERA, R. D.1 aCHAVES, F. C. M.1 aMONTEIRO, W. M.1 aSILVA, F. M. A. da1 aKOOLEN, H. H. F.1 aBOECHAT, A. L.1 aSARTIM, M. A.  tBiomoleculesgv. 12, art. 1208, 2022.