01998naa a2200217 a 450000100080000000500110000800800410001902400520006010000170011224500880012926000090021752013110022665300230153765300240156065300410158465300170162570000260164270000140166870000250168277300730170721438462022-06-08       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s11274-022-03313-52DOI1 aTRINCHEZ, D.  aRecent progress in the microbial production of xylonic acid.h[electronic resource]  c2022  aInterest in the production of renewable chemicals from biomass has increased in the past years. Among these chemicals, carboxylic acids represent a significant part of the most desirable bio-based products. Xylonic acid is a five-carbon sugar-acid obtained from xylose oxidation that can be used in several industrial applications, including food, pharmaceutical, and con-struction industries. So far, the production of xylonic acid has not yet been available at an industrial scale; however, several microbial bio-based production processes are under development. This review summarizes the recent advances in pathway characterization, genetic engineering, and fermentative strategies to improve xylonic acid production by microorganisms from xylose or lignocellulosic hydrolysates. In addition, the strengths of the available microbial strains and processes and the major requirements for achieving biotechnological production of xylonic acid at a commercial scale are discussed. Efficient native and engineered microbial strains have been reported. Xylonic acid titers as high as 586 and 171 g L −1 were obtained from bacterial and yeast strains, respectively, in a laboratory medium. Furthermore, relevant academic and industrial players associated with xylonic acid production will be presented.  aBio-based products  aBiomass hydrolysate  aMicrobial carboxylic acid production  aXylonic acid1 aCARNEIRO, C. V. G. C.1 aBRAGA, M.1 aALMEIDA, J. R. M. de  tWorld Journal of Microbiology and Biotechnologygv.38, n. 127, 2022.