02568naa a2200349 a 450000100080000000500110000800800410001902400480006010000180010824501530012626000090027950000390028852014500032765000210177765000230179865000100182165000140183165000200184565000120186565300210187770000170189870000200191570000230193570000220195870000230198070000190200370000330202270000170205570000230207270000250209577300980212021344262022-03-24       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1093/trstmh/trab1132DOI1 aMEURER, I. R.  aSeroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state.h[electronic resource]  c2022  aPublicado online em: 26 jul. 2021.  aBackground: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and underreported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state. Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Risk factors for infections and spatial clusters for both C. burnetii-seropositive individuals and livestock concentration were evaluated. Results: We found that 21 samples (4.8%; 95% CI 3.0 to 7.2%) were reactive for at least one class of anti-C. burnetii antibodies (titer of maior igual 64), with rural residence (p=0.036) being a risk factor. Also, two spatial clusters of seropositivity were found within a significant area by Scan, and a probable relationship between the Scan result and the livestock concentration by area was found. Conclusions: Seropositive individuals were associated with rural residence, with a likely relationship with the livestock concentration. Thus, this study establishes baseline figures for C. burnetii seroprevalence in humans ina state of Brazil, allowing the monitoring of trends and setting of control targets, as well as more representative longitudinal and risk analysis studies.  aComunidade Rural  aConstrução Rural  aFebre  aPecuária  aSaúde Pública  aZoonose  aSoroprevalência1 aSILVA, M. R.1 aSILVA, M. V. F.1 aDURÉ, A. I. de L.1 aADELINO, T. E. R.1 aCOSTA, A. V. B. da1 aVANELLI, C. P.1 aGUIMARÃES, R. J. de P. S. e1 aROZENTAL, T.1 aLEMOS, E. R. S. de1 aCORRÊA, J. O. do A.  tTransactions of the Royal Society of Tropical Medicine and Hygienegv. 116, p. 261-269, 2022.