02221naa a2200301 a 450000100080000000500110000800800410001902400430006010000200010324501120012326000090023552013550024465000160159965000140161565000110162965000240164065300220166465300170168665300200170365300150172365300140173865300160175265300270176870000200179570000190181570000170183477300680185121333292021-08-09       2020    bl uuuu     u00u1 u    #d7 ahtttps://doi.org./10.1071/RD192782DOI1 aSIQUEIRA, L. G.  aConsequences of assisted reproductive technologies for offspring function in cattle.h[electronic resource]  c2020  aAbnormal fetuses, neonates and adult offspring derived by assisted reproductive technologies (ART) have been reported in humans, rodents and domestic animals. The use of ART has also been associated with an increased likelihood of certain adult diseases. These abnormalities may arise as a result of an excess of or missing maternally derived molecules during in vitro culture, because the in vitro environment is artificial and suboptimal for embryo development. Nonetheless, the success of ART in overcoming infertility or improving livestock genetics is undeniable. Limitations of in vitro embryo production (IVEP) in cattle include lower rates of the establishment and maintenance of pregnancy and an increased incidence of neonatal morbidity and mortality. Moreover, recent studies demonstrated long-term effects of IVEP in cattle, including increased postnatal mortality, altered growth and a slight reduction in the performance of adult dairy cows. This review addresses the effects of an altered preimplantation environment on embryo and fetal programming and offspring development. We discuss cellular and molecular responses of the embryo to the maternal environment, how ART may disturb programming, the possible role of epigenetic effects as a mechanism for altered phenotypes and long-term effects of ART that manifest in postnatal life.  aEpigenetics  aPregnancy  aBovino  aReprodução Animal  aEmbrião in vitro  aEpigenética  aIn vitro embryo  aPós-natal  aPostnatal  aProgramming  aReprodução assistida1 aSILVA, M. V. G.1 aPANETTO, J. C.1 aVIANA, J. H.  tReproduction, Fertility and Developmentgv. 32, p. 82-97, 2020.