02391naa a2200349 a 450000100080000000500110000800800410001902200140006002400590007410000170013324501430015026000090029352013350030265000250163765000190166265000180168165000310169965000090173065000270173965000270176665000190179365000220181265000090183465300430184370000190188670000180190570000200192370000190194370000150196270000170197777300470199421328132022-03-15       2021    bl uuuu     u00u1 u    #d  a0045-65357 ahttps://doi.org/10.1016/j.chemosphere.2020.1280162DOI1 aJORGE, B. C.  aExposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats.h[electronic resource]  c2021  aAbstract: Benzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction. However, consequences of prepubertal BaP exposure and its impacts on adult life are yet unknown. This study investigated the effects of BaP exposure from the juvenile period to peripubertal on reproductive parameters in adult male rats. Males were exposed to 0; 0.1; 1 or 10 microgram/kg/day of BaP from post-natal (PND) 23 to PND 53 (by gavage). The lowest dose of BaP was able to compromise the male copulatory behavior, as evidenced by the delay in the first mount, intromission and ejaculation. Furthermore, BaP-treated groups showed lower sperm quality (disrupted motility and morphology) and quantity, reduced relative weights of the thyroid and seminal gland. Serum testosterone levels and the Leydig cells nuclei volume were decreased by BaP exposure whereas the StAR expression was increased. Histopathological changes in the testis also were detected in the males exposed to BaP. These results showed that prepubertal BaP-exposure adversely influenced the male reproductive system in the adult life, indicating that a comprehensive risk assessment of BaP-exposure on prepubertal period is necessary.  aAbnormal development  aBenzo(a)pyrene  aEcotoxicology  aHealth effects assessments  aRats  aReproductive disorders  aFisiologia Reprodutiva  aHidrocarboneto  aImpacto Ambiental  aRato  aHidrocarboneto policíclico aromático1 aREIS, A. C. C.1 aSTERDE, E. T.1 aBALIN, P. da S.1 aSCARANO, W. R.1 aHISANO, H.1 aARENA, A. C.  tChemospheregv. 263, article 128016, 2021.