03572naa a2200409 a 450000100080000000500110000800800410001902200140006002400510007410000200012524501250014526000090027030000100027952023860028965000200267565000140269565000100270965000160271965000180273565000250275365000110277865300280278965300210281765300230283865300230286165300270288465300230291165300330293470000220296770000210298970000180301070000190302870000210304770000150306870000240308377300550310721323352021-06-17       2021    bl uuuu     u00u1 u    #d  a0921-44887 adoi.org/10.1016/j.smallrumres.2021.1064472DOI1 aHAEHLING, M. B.  aIs selection for resistance and resilience to Haemonchus contortus possible in Morada Nova sheep?h[electronic resource]  c2021  a10 p.  aGastrointestinal nematodes (GIN) are a major constraint for sheep production. Selection of animals resistant to GIN infection is an effective and sustainable control strategy. In this study, the possibility of selection for resistance and resilience, as well as potential correlated responses, were evaluated. A total of 256 lambs and 123 ewes were submitted to two consecutive independent artificial infections with 4,000 infective larvae (L3) of Haemonchus contortus. Records of faecal egg count (FEC), packed cell volume (PCV), and body weight (BW) were taken serially until day 42 after infection in both challenges. Estimates of genetic parameters were obtained for individual records (in lambs) and for overall traits (in lambs and ewes) using mixed models. Phenotypic and genetic correlations were estimated between traits in lambs, with genetic correlations being based on estimated breeding values (EBVs). In addition, correlations between FEC in lambs and FEC in ewes, as well as PCV in lambs and ewes, were calculated. Heritability estimates for FEC in the first and second parasite challenge were, respectively, 0.25 ± 0.18 and 0.46 ± 0.19 for lambs, and 0.00 ± 0.09 and 0.20 ± 0.16 for ewes. For PCV, heritability estimates were 0.23 ± 0.14 and 0.32 ± 0.16 for lambs and 0.13 ± 0.11 and 0.37 ± 0.18 for ewes. For the overall daily weight gain (DWG), the heritability estimate was 0.70 ± 0.21. No significant genetic correlation was found between DWG and the other traits, while there was a negative genetic correlation between FEC and PCV (-0.70 ± 0.03). Genetic correlations of FEC and PCV between lambs and ewes were 0.36 ± 0.08 and 0.42 ± 0.08, respectively. The results of the present study suggest that selection for low FEC, high PCV and high BW/DWG is possible in Morada Nova lambs. Furthermore, selection for low FEC should have a correlated response on PCV (leading to higher PCV), while no correlated response is expected on DWG. Selection for low FEC in lambs would, in future generations, lead to higher resistance of lambs and also of ewes. Simultaneous selection for all three traits is possible in Morada Nova lambs, which would increase performance, decrease losses due to parasite infection and reduce the need for anthelmintic treatments, with beneficial consequences regarding selection pressure on parasite populations and productivity.  aFecal egg count  aParasites  aSheep  aWeight gain  aGanho de Peso  aHaemonchus Contortus  aOvelha  aContagem de ovos fecais  aFaecal egg count  aGenetic parameters  aPacked cell volume  aParâmetros genéticos  aParasite challenge  aVolume de células embaladas1 aTOSCANO, J. H. B.1 aGIRALDELO, L. A.1 aSANTOS, I. B.1 aESTEVES, S. N.1 aBENAVIDES, M. V.1 aTHOLON, P.1 aCHAGAS, A. C. de S.  tSmall Ruminant Researchgv.201, aug. 2021, 106447.