02176naa a2200241 a 450000100080000000500110000800800410001902400440006010000230010424501690012726000090029652013960030565000200170170000230172170000180174470000210176270000180178370000220180170000260182370000180184970000190186777300480188621320682021-09-28       2021    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1039/D0FO03388J2DOI1 aTHEODORO, J. M. V.  aGerminated millet flour (Pennisetum Glaucum (L.) R. BR.) improves adipogenesis and glucose metabolism and maintains thyroid function in vivo.h[electronic resource]  c2021  aThis study investigated the effects of germinated millet flour on adipogenesis, insulin resistance, glucose tolerance and thyroid function in Wistar rats fed with a high-fat high-fructose diet (HFHF). The experiment was divided into two phases. Phase 1: control group, which received AIN-93M diet (n = 10) and HFHF group (n = 20), which received a diet rich in saturated fat (31%) and fructose (20%), for eight weeks. Phase 2: intervention: the control group maintained the AIN-93M diet (n = 10) and the HFHF group was divided into two groups: the HFHF (n = 10) and the germinated millet group (n = 10), for 10 weeks. The germinated millet flour maintained (p&gt0, 05) the plasma levels of thyroid hormones, increased (p&lt0.05) the protein kinase B (AKT) mRNA expression and the phospho-AKT1 protein concentration, the phosphofructokinase (PFK) mRNA and activated protein kinase (AMPK) mRNA expression, and the brown adipose tissue and reduced (p&lt0.05) the glucose triglyceride index (TyG), glucose, insulin and hypercorticosteronemia, compared to the HFHF group. These effects contributed to reduce the gluconeogenesis, hyperinsulinemia and adiposity. Thus, germinated millet flour is a good alternative for modulating the adipogenesis and glucose metabolism, without interfering with the thyroid hormones, in rats with an insulin resistance condition with a high-fat high-fructose diet.  aFood technology1 aMARTINEZ, O. D. M.1 aGRANCIERI, M.1 aTOLEDO, R. C. L.1 aBINOTI, M. L.1 aMARTINS, A. M. D.1 aCARVALHO, C. W. P. de1 aLISBOA, P. C.1 aMARTINO, H. S.  tFood & Functiongv. 12, p. 6083-6090, 2021.