02398naa a2200385 a 450000100080000000500110000800800410001902200140006002400520007410000180012624501070014426000090025152012920026065000240155265000180157665000180159465000150161265000140162765000090164165000170165065000270166765000220169465000130171665000120172965000120174165300280175365300250178170000230180670000270182970000200185670000220187670000180189870000200191677300760193621310612021-08-09       2021    bl uuuu     u00u1 u    #d  a1382-66897 ahttps://doi.org/10.1016/j.etap.2020.1035462DOI1 aBECARO, A. A.  aEffects of silver nanoparticles prenatal exposure on rat offspring development.h[electronic resource]  c2021  aAbstract: Abstract: Many types of nanocomposites employed in food packaging are based on silver nanoparticles (AgNP) because of their antibacterial properties, which can increase food shelf-life. As the commercialization of AgNP products has been expanding, the released of such nanoparticles in the environment has caused enormous concern, once they can pose potential risks to the environment and human beings. For instance, exposure of the maternal environment to nanomaterials during pregnancy may impact the health of the dam, fetus and offspring. In this context, here we investigated the effects of prenatal exposure of AgNP on the pregnancy outcomes of dams and postnatal development of their offspring. Pregnant Wistar rats were exposed to distinct AgNP concentrations (0, 1, 3 and 5 micrograms/kg/day) from beginning to the end of pregnancy. At parturition, newborns were observed regarding clinical signs of toxicity and survival rate. The offspring was examined by evaluating developmental endpoints. A delay in time for vaginal opening and testes descent were detected in the offspring exposed to AgNP during embryonic development. Our results indicate that prenatal exposure to AgNP can compromise neonatal rats' postnatal development, especially the reproductive features.  aAnimal reproduction  aEcotoxicology  aNanomaterials  aNanosilver  apregnancy  arats  areproduction  aAnimal de Laboratório  aComposto Químico  aEmbrião  aPrenhez  aToxidez  aDevelopmental endpoints  aSilver nanoparticles1 aOLIVEIRA, L. P. de1 aCASTRO, V. L. S. S. de1 aSIQUEIRA, M. C.1 aBRANDAO, H. de M.1 aCORREA, D. S.1 aFERREIRA, M. D.  tEnvironmental Toxicology and Pharmacologygv. 81, article 103546, 2021.