02580naa a2200229 a 450000100080000000500110000800800410001902400510006010000230011124501900013426000090032452018000033365000200213370000230215370000180217670000210219470000190221570000160223470000260225070000220227677300520229821306832021-05-27       2021    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.jcs.2021.1032072DOI1 aTHEODORO, J. M. V.  aGerminated millet flour (Pennisetum glaucum (L.) R. Br.) reduces inflammation, oxidative stress, and liver steatosis in rats fed with high-fat high-fructose diet.h[electronic resource]  c2021  aThis study investigated the effects of germinated millet flour on inflammation, oxidative stress, adiposity, and liver steatosis in Wistar rats fed with a high-fat high-fructose diet. In phase 1 of the experiment (8 weeks) the animals were separated into a control group with an AIN-93M diet (n = 10) and a high-fat high-fructose group (HFHF) (n = 20) with a diet rich in saturated fat (31%) and fructose (20%). In phase 2 (10 weeks), the control group was maintained on the AIN-93M diet (n = 10) and the HFHF group was divided into HFHF group (HFHF diet, n = 10) and the Millet group (HFHF with germinated millet flour replacing 43.6% dietary fiber, 100% starch, 36% protein and 39% oil in the experimental diet, n = 10). The germinated millet flour reduced (p &lt 0.05), in comparison with HFHF group, the adiposity (24.18 ± 4.45g to millet and 32.89 ± 8.46g to HFHF), triglycerides (100.00 ± 17.93g to millet and 147.8 ± 21.57g to HFHF), uric acid, ALT, NF-kB (131.9 ± 97.14 pg/ml to millet and 346.3 ± 58.88 pg/ml to HFHF), (98.80 ± 19.90 pg/ml to millet and 141.4 ± 25.12 pg/ml to HFHF), platelet/lymphocyte and neutrophil/lymphocyte ratio, liver steatosis, inflammatory infiltrate (0.1880 ± 0.07 pg/ml to millet and 1.269 ± 0.17 pg/ml to HFHF), MDA levels, and liver collagen deposition. Further, germinated millet increased (p &lt 0.05) IL-10 (1511 ± 528.50 pg/ml to millet and 483.8 ± 91.59 pg/ml to HFHF), PPAR protein, total antioxidant capacity of the liver (0.2825 ± 0.04 pg/ml to millet and 0.2075 ± 0.05 pg/ml to HFHF) and the activity of SOD and catalase, compared to HFHF group. Thus, germinated millet flour was able to reduce adiposity and liver steatosis and presented anti-inflammatory and antioxidant effects, which highlight its functional biological effects.  aFood technology1 aMARTINEZ, O. D. M.1 aGRANCIERI, M.1 aTOLEDO, R. C. L.1 aMARTINS, A. D.1 aDIAS, D. M.1 aCARVALHO, C. W. P. de1 aMARTINO, H. S. D.  tJournal of Cereal Sciencegv. 99, 103207, 2021.