02362naa a2200241 a 450000100080000000500110000800800410001902200140006010000170007424501320009126000090022352016560023265000190188865000160190765300180192370000210194170000210196270000240198370000220200770000180202970000210204777300520206821289662021-01-08       2020    bl uuuu     u00u1 u    #d  a0921-44881 aFERREIRA, L.  aUCP2 and PPARG gene polymorphisms and their association with milk yield and composition traits in goats.h[electronic resource]  c2020  aWith the present study, we aimed to identify polymorphisms in the genes encoding mitochondrial uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor gamma (PPARG), and to evaluate their associations with breeding values for milk production and composition traits in goats. Breeding values were estimated from milk yield and composition data of Saanen and Alpine animals using a single-trait model. The number of animals used for the estimation of breeding values ranged from 1,094 to 1,292, depending on the trait studied. After identification of the polymorphisms, the animals were genotyped for association analysis. Among animals with estimated breeding values, we randomly genotyped 185 for the UCP2.29614171G/A polymorphism located in the promoter region of the UCP2 gene, 176 for the UCP2.29615319G/A polymorphism located in exon 2 of the UCP2 gene, and 194 for the PPARG-A/B polymorphism located in the promoter region of the PPARG gene. For the UCP2 gene, the UCP2.29614171G/A polymorphism showed association (P &lt 0.05) with milk fat, milk protein and milk dry extract content, while the UCP2.29615319G/A polymorphism was associated (P &lt 0.05) with the breeding values for milk protein, milk dry extract and milk lactose content. For the PPARG gene, the PPARG-A/B polymorphism showed association (P &lt 0.05) with milk, protein, dry extract, and lactose yields, as well as with milk lactose content. Our results present new data about genetic diversity in goats, and demonstrate associations between polymorphisms in UCP2 and PPARG genes with goats estimated breeding values for milk production and composition traits.  aBreeding value  aDairy goats  aSaanen Alpine1 aSOARES. M. A. M.1 aRODRIGUES, M. T.1 aARAUJO, J. L. S. de1 aMELO, A. L. P. de1 aGASPARINI, E.1 aGARCIA, O. S. R.  tSmall Ruminant Researchgv. 192, e106210, 2020.