01590naa a2200289 a 450000100080000000500110000800800410001902200150006002400530007510000200012824500910014826000090023952007590024865000140100765000160102165000180103765000250105565300230108065300180110365300260112165300120114770000250115970000190118470000280120370000190123177300500125021288202020-12-29       2020    bl uuuu     u00u1 u    #d  a2446 -47757 ahttps://doi.org/10.32712/2446-4775.2020.8212DOI1 aCERDEIRA, A. L.  aCryptomeria japonica (L. F.) D. Don as source of shikimic acid.h[electronic resource]  c2020  aResumo: Oseltamivir phosphate (OSP), marketed under the brand name of Tamiflu®, is a potent inhibitor of viral neuraminidase, a glycoside hydrolase enzyme essential for viral replication. OSP is also important to control influenza virus (H1N1) and is produced mainly from shikimic acid (SA) extracted from plants. The main source of SA is from seeds of I. verum. Alternatives to meet the worldwide demand are necessary. One of this is Cryptomeria japonica. In this study, we found a content of 56.36 mg.kg-1 of SA in dried biomass for C. japonica, while for I.verum, the traditional source, was 96.57 mg.kg-1. Due to the fact of C. japonica is a tree, exploited for commercial production, it can be a renewable and reliable source SA for OSP production.  ainfluenza  aOseltamivir  aShikimic acid  aCryptomeria Japonica  aÁcido chiquímico  aNeuraminidase  aOseltamivir phosphate  aTamiflu1 aQUEIROZ, S. C. N. de1 aMATALLO, M. B.1 aQUEIROZ, S. C. do N. de1 aMATALLO, M. B.  tRevista Fitosgv. 14, n. 4, p. 462-468, 2020.