02269naa a2200409 a 450000100080000000500110000800800410001902400520006010000170011224501530012926000090028252010440029165000180133565000200135365000280137365000150140165000270141665000080144365300270145165300190147865300160149765300210151365300220153465300230155665300190157965300260159865300110162470000150163570000170165070000190166770000180168670000170170470000210172170000170174270000190175977300810177821283042021-12-08       2021    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.msec.2020.1115512DOI1 aCOSTA, J. R.  aPolymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.h[electronic resource]  c2021  aGrape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health. However, bioaccessibility is often poor due to their degradation during digestion. This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract. Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency. The best formulations showed sizes ranging 523–853 nm, polydispersity indexes of 0.11–0.36, zeta potential of ?15.0–14.9 mV and TP association efficiencies of 68 and 65%. FTIR confirmed that there was no formation of new chemical groups after association of the polymers with GPE. Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.  aEncapsulation  aFood technology  aIndústria Alimentícia  aSubproduto  aTecnologia de Alimento  aUva  aAntimicrobial Cellular  aAntimicrobiano  aAntioxidant  aBioaccessibility  aBioacessibilidade  aCaptação celular  aEncapsulamento  aIndustrial by-product  aUptake1 aXAVIER, M.1 aAMADO, I. R.1 aGONÇALVES, C.1 aCASTRO, P. M.1 aTONON, R. V.1 aCABRAL, L. M. C.1 aPASTRANA, L.1 aPINTADO, M. E.  tMaterials Science & Engineering Cgv. 119, Feb. 2021, 111551, 2021. p. 1-13.