01960naa a2200301 a 450000100080000000500110000800800410001902400440006010000190010424501550012326000090027852010400028765000210132765000290134865000200137765000120139765000240140965300230143370000220145670000160147870000140149470000220150870000240153070000220155470000180157670000160159477300480161021271872023-05-08       2020    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1039/D0FO02256J2DOI1 aLIMA, G. G. de  aCharacterisation and in vivo evaluation of Araucaria angustifolia pinhão seed coat nanosuspension as a functional food source.h[electronic resource]  c2020  aAraucaria angustifolia seeds from South America are culturally important; however, the seed coat is generally discarded and it has yet to find a beneficial commercial impact. Herein, we propose a new formulation for the use of the seed coat for the production of a food source. A nanosuspension was developed under two conditions, bleached and unbleached treatment. Initial characterisation of the seed coat, as well as the nanosuspension, was conducted, in which nanofibrils with antioxidant activity and high values of phenol and sterol classes with health-promoting ability were detected by GC-MS; however, after bleaching, the compounds were removed. The nanosuspension induced a decrease in cholesterol, triglycerides, glucose levels and weight gain when added to the daily rat diet. No significant differences were determined when bleach treatment was used, suggesting that dietary fibre plays a more significant role. Histology analysis and biochemical markers reported no toxicity from the rat ingestion of the nanoformulation.  aFunctional foods  aAraucária Angustifólia  aEspécie Nativa  aPinhão  aPinheiro do Paraná  aAlimento funcional1 aMIRANDA, N. B. de1 aTIMM, T. G.1 aMATOS, M.1 aLIMA, T. A. M. de1 aMAGALHAES, W. L. E.1 aTAVARES, L. B. B.1 aHANSEL, F. A.1 aHELM, C. V.  tFood & Functiongv. 11, p. 9820-9832, 2020.