02610naa a2200493 a 450000100080000000500110000800800410001902400430006010000210010324502330012426000090035752010830036665000170144965000220146665000260148865000170151465000190153165000180155065000130156865000200158165000220160165000090162365300270163265300360165965300380169565300180173365300180175165300170176970000200178670000190180670000200182570000220184570000220186770000230188970000220191270000180193470000200195270000160197270000170198870000170200570000250202270000180204777300510206521255732022-08-22       2020    bl uuuu     u00u1 u    #d7 aDOI: 10.1016/j.phytol.2020.09.0032DOI1 aGUEDES, J. A. C.  aComparative analyses of metabolic fingerprint integrated with cytotoxic activity and in silico approaches of the leaves extract of Spondias mombin L. and Spondias tuberosa Arr. Cam. from Northeast, Brazil.h[electronic resource]  c2020  aSpondias species are a relevant source of natural-bioactive compounds in Brazilian folk medicine, and its biological potential has not been explored. Thus, this study aimed to determine the metabolomic fingerprint of Spondias mombin and Spondias tuberosa leaves based on the use of reversed-phase liquid chromatography coupled to a high-resolution mass spectrometer (UPLC-HRMS). The analysis by UPLC-HRMS allowed the annotation of 31 metabolites. The multivariate analysis allowed us to identify the biomarkers responsible for the distinction between species. Also, we correlate the biomarkers of S. mombin and S. tuberosa as supposed responsible for the difference in the degree of cytotoxicity between them. The in silico evaluation was performed to give more consistency to the correlation between biomarkers and cytotoxicity, which were compared to commercial drugs. Therefore, this study showed that S. mombin has the potential to become an input for the pharmaceutical industry as a source of raw material that can positively impact the sectors of agricultural production.  aChemometrics  aDialium guineense  aLiquid chromatography  aMetabolomics  aYellow mombins  aAnacardiaceae  aCaatinga  aSpondias Mombin  aSpondias Tuberosa  aUmbu  aCromatografia líquida  aEspectrometria de massa de alta  aHigh-resolution mass spectrometry  aMetabolômica  aPlanta nativa  aQuimiometria1 aSANTIAGO, Y. G.1 aLUZ, L. dos R.1 aSILVA, M. F. S.1 aRAMIRES, C. M. C.1 aLIMA, M. A. C. de1 aOLIVEIRA, V. R. de1 aPESSOA. C. do Ó.1 aCANUTO, K. M.1 aBRITO, E. S. de1 aLIMA, M. F.1 aALVES, R. E.1 aZAMPIERI, D.1 aNASCIMENTO, R. F. do1 aZOCOLO, G. J.  tPhytochemistry Lettersgv. 40, p. 26-36, 2020.