02311naa a2200349 a 450000100080000000500110000800800410001902400320006010000190009224501330011126000090024430000100025352013370026365000130160065000140161365300140162765300160164165300130165765300140167065300090168465300170169365300150171065300130172570000200173870000180175870000180177670000200179470000200181470000170183470000170185177300930186821252832020-10-05       2020    bl uuuu     u00u1 u    #d7 a10.3390/ijerph171864562DOI1 aCOLNAGO, L. A.  aSimple, low-cost and long-lasting film for virus inactivation using avian coronavirus model as challenge.h[electronic resource]  c2020  a1 - 9  aAbstract: The COVID-19 infection, caused by SARS-CoV-2, is inequitably distributed and more lethal among populations with lower socioeconomic status. Direct contact with contaminated surfaces has been among the virus sources, as it remains infective up to days. Several disinfectants have been shown to inactivate SARS-CoV-2, but they rapidly evaporate, are flammable or toxic and may be scarce or inexistent for vulnerable populations. Therefore, we are proposing simple, easy to prepare, low-cost and effcient antiviral films, made with a widely available dishwashing detergent, which can be spread on hands and inanimate surfaces and is expected to maintain virucidal activity for longer periods than the current sanitizers. Avian coronavirus (ACoV) was used as model of the challenge to test the antivirus effcacy of the proposed films. Polystyrene petri dishes were covered with a thin layer of detergent formula. After drying, the films were exposed to different virus doses for 10 min and virus infectivity was determined using embryonated chicken eggs, and RNA virus quantification in allantoic fluids by RT-qPCR. The films inactivated the ACoV (ranging from 103.7 to 106.7 EID50), which is chemically and morphologically similar to SARS-CoV-2, and may constitute an excellent alternative to minimize the spread of COVID-19.  aAviário  aVirologia  aAntiviral  aCoronavirus  aCOVID-19  aDetergent  aFilm  aSanitization  aSARS-CoV-2  aVirucide1 aTREVISOL, I. M.1 aVOSS RECH, D.1 aFORATO, L. A.1 aMITRE, C. I. N.1 aLEITE, J. P. G.1 aGIGLIOTI, R.1 aOKINO, C. H.  tInternational Journal of Environmental Research and Public Healthgv. 17, a. 6456, 2020.