02500naa a2200277 a 450000100080000000500110000800800410001902400520006010000170011224501510012926000090028052016630028965000180195265300180197065300230198865300120201165300140202365300140203765300170205170000160206870000230208470000200210770000280212770000240215577300430217921217632024-05-03 2020 bl uuuu u00u1 u #d7 ahttps://doi.org/10.1007/s10570-020-03129-22DOI1 aCLARO, F. C. aLow cost membrane of wood nanocellulose obtained by mechanical defibrillation for potential applications as wound dressing.h[electronic resource] c2020 aLarge wounds are characterized by clini-cal and surgical challenges, requiring numeroussearches on demand for inexpensive biocompatiblematerials that produce the best quality of cutaneoushealing. Cellulose is a biopolymer of greatest abun-dance, good biocompatibility and wide applicationdue to its chemical and physical properties. This studywas aimed to develop and characterize low costmembranes of wood cellulose nanofibrils for potentialapplication as a wound dressing in comparison to acommercial porous regenerating membrane. An inex-pensive mechanical method was used to defibrillatecellulose, and later the membranes were obtained fromthe nanofibrils by filtering and drying under mildpressure. The techniques employed for characteriza-tion included scanning electron microscopy, physicaltesting, application in vivo and cost-effectivenessanalysis. The membranes presented promising phys-ical properties for application as cutaneous dressing,with characteristic translucency allowing the evalua-tion of the wound without the need of removal andexchange of the dressing. Wood nanocellulose dress-ing seems to be promising for wound care since itpresented good adhesion to the moist wound surfacesthus promoting the most efficient repitialization in thefirst 4 days. No allergic reaction or inflammatoryresponse to wood nanocellulose dressings wasobserved. The wood nanocellulose membranes standout as a potential wound dressing, as it shows similarefficacy of bacterial cellulose dressing. Besides theefficacy, the membrane developed in this studypresents a simpler, faster and cheaper manufacturingprocess, which may reduce the production cost by99% aNanomaterials aBiocompatible aCost-effectiveness aHealing aNanofiber aNanofibra aNanomaterial1 aJORDÃO, C.1 aVIVEIROS, B. M. de1 aISAKA, L. J. E.1 aVILLANOVA JUNIOR, J. A.1 aMAGALHAES, W. L. E. tCellulosegv. 7, p. 10765-10779, 2020.