02188naa a2200253 a 450000100080000000500110000800800410001902200140006002400350007410000180010924501340012726000090026152014210027065300300169165300250172165300170174665300150176370000200177870000180179870000170181670000220183370000190185577300600187421216532024-12-11       2020    bl uuuu     u00u1 u    #d  a1090-78777 a10.1016/j.jmr.2019.1066662DOI1 aMONARETTO, T.  aUsing T1 as a direct detection dimension in two-dimensional time-domain NMR experiments using CWFP regime.h[electronic resource]  c2020  aThe transverse relaxation time (T 2), measured with Carr-Purcell-Meiboom-Gill (CPMG) sequence, has been widely used to obtain the direct dimension data in two-dimension time domain NMR (2D TDNMR). In this paper we are demonstrating that Continuous Wave Free Precession sequence, with low flip angle (CWFP-T1 ), can be an alternative to CPMG as direct detection dimension. CWFP-T 1 is a fast single shot sequence, like CPMG, and yields an exponential signal governed predominantly by the longitudinal (T1 ) relaxation time. To obtain the correlations between T1 and T2 (T 1-T 2 maps) we are proposing the use of CPMG-CWFP-T 1 pulse sequence. In this sequence CPMG encodes T 2 information (indirect dimension) that modulates the CWFP-T 1 (direct dimension) signal amplitudes. CPMG-CWFP-T 1 experiments were compared with classical 2D sequences such as Saturation-Recovery-CPMG (SR-CPMG) and InversionRecovery-CPMG (IR-CPMG) sequence and yields similar results in phantom sample. The experimental time for the 2D sequences, using single scan, shows that SR-CPMG #20; CPMG-CWFP-T 1 &lt IR-CPMG.Experimental and simulated results demonstrated that 2D-CPMG-CWFP-T 1 maps have higher resolution in T1 dimension than the techniques that uses CPMG as direct dimension. CPMG-CWFP-T1 sequence was also applied to study beef samples, and 2D maps showed higher resolution in the two fat signals than the classical IR-CPMG method.  a2 D TD NMR pulse sequence  a2D Laplace transform  aCPMG CWFP T1  aT1 T2 maps1 aMONTRAZI, E. T.1 aMORAES, T. B.1 aSOUZA, A. A.1 aRONDEAU-MOURO, C.1 aCOLNAGO, L. A.  tJournal of Magnetic Resonancegn. 311, a. 106666, 2020.