02008naa a2200289 a 450000100080000000500110000800800410001902400550006010000220011524501320013726000090026952010760027865300170135465300150137165300260138665300190141265300280143170000250145970000230148470000220150770000260152970000240155570000160157970000220159570000130161777300880163021181882024-02-06       2019    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1080/09205063.2019.16466272DOI1 aZANETTE, R. S. S.  aCotton cellulose nanofiber/chitosan nanocompositebcharacterization and evaluation of cytocompatibility.h[electronic resource]  c2019  aCellulose is a renewable polymer quite abundant on the Earth and very attractive for applications in the construction of eco-friendly biomedical products. The aim of this study was to investigate the chemical-physical characteristics of cotton cellulose nanofiber (CCN)/chitosan nanocomposite and its cytocompatibility with human embryonic kidney cells. First, the chemical composition, swelling ratio and surface topography of the nanocomposite were evaluated. Cytocompatibility was then assessed through spreading, proliferation and viability of cells. The experimental results showed that the CCN was an effective nanomaterial agent for increasing the roughness surface of chitosan film. Cell proliferation and changes in cell morphology indicated that the nanocomposite led to improved cell spreading and growth. Cell viability did not decrease after 24 h. However, the cell survival on the nanocomposite was affected at 72 h. The results indicate that CCN/chitosan nanocomposite could be a promising biocompatible biomaterial for biomedical applications.  aBiomaterials  aBiopolymer  aIn vitro cell culture  aNanotopography  aPolymeric nanomaterials1 aALMEIDA, L. B. F. DE1 aSOUZA, N. L. G. D.1 aALMEIDA, C. G. DE1 aOLIVEIRA, L. F. C. DE1 aMATOS, ELYABE M. DE1 aGERN, J. C.1 aBRANDAO, H. de M.1 aMUNK, M.  tJournal of Biomaterials Science, Polymer Editiongv. 30, n. 16, p. 1489-1504, 2019.