02354naa a2200493 a 450000100080000000500110000800800410001902200140006002400490007410000200012324501230014326000090026652009770027565000150125265000180126765000150128565000140130065000170131465000170133165000210134865000160136965000250138565000260141065000270143665000140146370000270147770000170150470000170152170000210153870000180155970000180157770000250159570000230162070000190164370000180166270000150168070000210169570000190171670000150173570000210175070000180177170000230178977300480181221153932019-11-28       2019    bl uuuu     u00u1 u    #d  a0036-80757 ahttps://doi.org/10.1126/science.aaw92852DOI1 aCARRIÓN, V. J.  aPathogen-induced activation of disease-suppressive functions in the endophytic root microbiome.h[electronic resource]  c2019  aAbstract: Microorganisms living inside plants can promote plant growth and health, but their genomic and functional diversity remain largely elusive. Here, metagenomics and network inference show that fungal infection of plant roots enriched for Chitinophagaceae and Flavobacteriaceae in the root endosphere and for chitinase genes and various unknown biosynthetic gene clusters encoding the production of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). After strain-level genome reconstruction, a consortium of Chitinophaga and Flavobacterium was designed that consistently suppressed fungal root disease. Site-directed mutagenesis then revealed that a previously unidentified NRPS-PKS gene cluster from Flavobacterium was essential for disease suppression by the endophytic consortium. Our results highlight that endophytic root microbiomes harbor a wealth of as yet unknown functional traits that, in concert, can protect the plant inside out.  aEndophytes  aFlavobacteria  aMicrobiome  aPathogens  aPlant growth  aPlant health  aPlant protection  aRhizosphere  aRhizosphere bacteria  aMicrobiologia do Solo  aPopulação Microbiana  aRizosfera1 aPEREZ-JARAMILLO, J. E.1 aCORDOVEZ, V.1 aTRACANNA, V.1 aHOLLANDER, M. de1 aRUIZ-BUCK, D.1 aMENDES, L. W.1 aIJCKEN, W. F. J. van1 aGOMEZ-EXPOSITO, R.1 aELSAYED, S. S.1 aMOHANRAJU, P.1 aARIFAH, A.1 aOOST, J. van der1 aPAULSON, J. N.1 aMENDES, R.1 aWEZEL, G. P. van1 aMEDEMA, M. H.1 aRAAIJMAKERS, J. M.  tSciencegv. 366, n. 6465, p. 606-612, 2019.