01884naa a2200253 a 450000100080000000500110000800800410001910000180006024501770007826000090025552011110026465000150137570000150139070000150140570000250142070000130144570000140145870000150147270000300148770000180151770000220153570000170155777300560157420970632018-12-13       2018    bl uuuu     u00u1 u    #d1 aRODRIGUES, R.  aLactobacillus rhamnosus EM1107 in goat milk matrix modulates intestinal inflammation involving NF-kB p65 and SOCs-1 in an acid-induced colitis model.h[electronic resource]  c2018  aInflammatory Bowel Diseases (IBD) is characterized by a deregulated immune response. Probiotics are able to modulate the intestinal microbiota and regulating inflammatory responses. This study evaluated the effect of pretreatment of Lactobacillus rhamnosus EM1107, isolated (EM1107) or added to goat cheese (LRC), on acetic acid-induced colitis in rats. EM1107 or LRC had a protective effect on intestinal inflammation, with the improvement of disease activity index and macroscopic damage caused by inflammation. It also reduced myeloperoxidase, TNF-?, IL-1? colonic levels and improved oxidative stress. The histological evaluation confirmed the beneficial effect in colonic tissue preservation. Intestinal immunohistochemical analysis revealed down-regulation of IL-17, NF-?B p65, MMP-2, MMP-9, and iNOS expression, up-regulation of SOCs-1, ZO-1 and MUC-2, which are important intestinal mucosal barrier proteins. These results suggest that Lactobacillus rhamnosus EM1107 alone or added to goat cheese exerts a preventive effect against acetic acid-induced damage and may be an alternative to human IBD.  aProbiotics1 aGUERRA, G.1 aSOARES, J.1 aSANTOS, K. M. O. dos1 aROLIM F.1 aASSIS, P.1 aARAUJO, D.1 aARAÚJO JÚNIOR, R. F. de1 aGARCIA, V. B.1 aARAÚJO, A. A. de1 aQUEIROGA, R.  tJournal of Functional Foodsgv. 50, p. 78-92, 2018.