01828naa a2200337 a 450000100080000000500110000800800410001910000170006024501280007726000090020552008720021465000130108665000310109965000170113065000310114765000210117865000150119965000100121465000130122465000240123765000250126165000170128665000150130365000190131865300180133770000160135570000150137170000160138670000160140277300720141820956202018-09-13       1987    bl uuuu     u00u1 u    #d1 aSMITH, W. D.  aMucosal IgA production and lymph cell traffic following prolonged low level infections of Ostertagia circumcincta in sheep.  c1987  aAbstract: Some aspects of the local immune response to daily challenge with 2000 Ostertagia circumcincta larvae were studied by monitoring changes in the composition of gastric lymph of naive and previously infected sheep. The main changes in the naive group were increases in lymphoblast output and concentrations of pepsinogen whereas lymph albumin values decreased markedly and IgA concentrations were usually unchanged. In contrast, in the previously infected sheep, the continuous challenge stimulated only transient increases in lymphoblast and IgA containing cell traffic whereas lymph IgA and pepsinogen concentrations remained elevated throughout the experiment. By temporarily interrupting the challenge in a second group of previously infected sheep it was shown that elevated IgA and pepsinogen values were maintained only if larval intake was continuous.  aAbomasum  aAnimal parasitic nematodes  aBiosynthesis  aGastrointestinal nematodes  aImmunoglobulin A  aImmunology  aLymph  aNematoda  aNematode infections  aOstertagia ostertagi  aParasitology  aPepsinogen  aSheep diseases  aOstertagiasis1 aJACKSON, F.1 aGRAHAM, R.1 aJACKSON, E.1 aWILLIAMS J.  tResearch in Veterinary Sciencegv. 43, n. 3, p. 320-326, Nov. 1987.