02736naa a2200373 a 450000100080000000500110000800800410001910000170006024500820007726000090015950000810016852016470024965000120189665000210190865000140192965000100194365000150195365000190196865000130198765000150200065000100201565000140202565300230203965300230206265300240208570000230210970000260213270000200215870000180217870000270219670000200222370000210224377300980226420928872018-07-24       2017    bl ---       0--  u    #d1 aSILVA, V. C.  aExperimental poisoning by cassava wastewater in sheep.h[electronic resource]  c2017  aTítulo em português:  Intoxicação experimental por manipueira em ovinos.  aThe processing of Manihot esculenta (cassava) tubers yield different by-products, including cassava wastewater, which is the liquid pressed out of the tuber after it has been  mechanically crushed. Cyanide poisoning after ingestion of cassava wastewater has been reported in ruminants and pigs in Northeastern Brazil. With the aim of studying its toxicity, cassava wastewater was administered orally to six sheep at doses of 0.99, 0.75,  0.70, 0.63, and 0.5 mg of hydrocyanic acid kg-1 body weight, which corresponded to 14.2, 10.6, 9.8, 8.89, and 7.1 mL of wastewater kg-1. On the second day, the sheep received a volume of wastewater which corresponded to 0.46, 0.34, 0.31, 0.28, and 0.23 mg of HCN kg-1. A sheep used as control received 9.9 mL of water kg-1 BW. Sheep that received from 0.75 to 0.99 mg kg-1 of HCN on the first day exhibited severe clinical signs of poisoning, and the sheep that received 0.63 and 0.5 mg kg-1 exhibited mild clinical signs. All sheep were successfully treated with sodium thiosulfate. On the second day, only the sheep that received 0.46 mg kg-1 and 0.34 mg kg-1 exhibited mild clinical signs and recovered spontaneously. The concentration of HCN in the wastewater was 71.69±2.19 ?g mL-1 immediately after production, 30.56±2.45  ?g mL-1 after 24 hours, and 24.25±1.28 ?g mL-1 after 48 hours. The picric acid paper test was strongly positive 5 minutes after production; moderately positive 24 hours after production, and negative 48 hours after production. We conclude that cassava wastewater is highly toxic to sheep if ingested immediately after production, but rapidly loses toxicity in 24-48 hours.  aCassava  aHydrogen cyanide  aRuminants  aSheep  aWastewater  aAcido prussico  aMandioca  aManipueira  aOvino  aRuminante  aÁcido cianídrico  aNordeste do Brasil  aNortheastern Brazil1 aOLIVEIRA, L. A. de1 aLACERDA, M. dos S. C.1 aPIMENTEL, L. A.1 aSANTOS, W. S.1 aMACÊDO, J. T. S. A. e1 aRIET-CORREA, F.1 aPEDROSO P. M. O.  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 37, n. 11, p. 1241-1246, novembro. 2017.