02557naa a2200277 a 450000100080000000500110000800800410001902200380006002400320009810000190013024502090014926000090035852016130036765000250198065000230200565000250202865300140205365300220206765300140208970000250210370000290212870000280215770000200218570000230220577300510222820901822018-05-04       2018    bl uuuu     u00u1 u    #d  a0248-1294 print, 1625-967X online7 a10.17660/th2018/73.2.22DOI1 aPEIXOTO, F. M.  aCharacterization and bioaccessibility of anthocyanins from blueberry (Vaccinium corymbosum L.) after simulated gastrointestinal digestionbA positive effect on malvidin derivatives.h[electronic resource]  c2018  aRecent studies have reported many preventive and therapeutic properties against cardiovascular disease and cancer, associated to the consumption of polyphenols, including anthocyanins. Anthocyanin bioavailability is a major issue regarding their biological effects, because the results are still controversial and divergent. Bioaccessibility and absorption studies represent the first steps in predicting bioavailability of the bioactive compounds in humans. The objectives of the current research were to perform an in vitro gastro-intestinal digestion model by mimicking oral, gastric and intestinal physiological conditions, in order to investigate the bioaccessibility of blueberry anthocyanins. Materials and methods – Identification and quantification of anthocyanins were carried out by HPLC and ESI-MS/MS detector. Results and discussion – Total anthocyanin content (125.27 ± 19.80 mg 100 g-1) was greatly decreased after digestion (6.50 ± 1.03 mg 100 g-1), which represented 5.20 ± 0.82% of bioaccessibility. All delphinidin derivatives were unstable, not detected after digestion, and had the lowest bioaccessible forms. Otherwise, malvidin derivatives, including the acetyl form, were stable and displayed the highest bioaccessibility percentage. More -OCH3 groups seems to increase the bioaccessibility, because higher structure size molecules can promote steric hindrance and impact on anthocyanin low degradation or conversion to non-detectable forms. Conclusion – These results should contribute to answer some questions concerning anthocyanin stability during gastro-intestinal path.  aantioxidant activity  ain vitro digestion  aVaccinium Corymbosum  aBlueberry  aNutritional value  aPhenolics1 aGOUVÊA, A. C. M. S.1 aSANTIAGO, M. C. P. de A.1 aMARTINS, Z. E. de S. V.1 aBORGUINI, R. G.1 aGODOY, R. L. de O.  tFruitsgv. 73, n. 2, p. 88-96, mar./apr. 2018.