02376naa a2200373 a 450000100080000000500110000800800410001910000230006024501120008326000090019550001520020452012060035665000140156265000220157665000190159865000250161765000100164265000100165265000130166265000120167565000190168765000110170665000120171765300150172965300230174465300140176770000210178170000240180270000250182670000200185170000220187170000180189377300910191120899892018-03-29       2018    bl uuuu     u00u1 u    #d1 aSOUZA, A. J. S. de  aHallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype.h[electronic resource]  c2018  aTítulo em português: Perfil das lesões histopatológicas hepáticas em suínos infectados naturalmente pelo genótipo 3 do vírus da hepatite E.  aHistopathological evaluation of liver from 33 pigs slaughtered for human consumption in Amazon region, previously tested by serology and molecular techniques for hepatitis E virus infection (HEV), was analysed in three groups: Group 1, negative for both HEV-RNA and anti-HEV IgG (n=10); Group 2, positive for HEV-RNA (n=13); Group 3, positive for anti- HEV IgG (n=10). Group 2 showed a significant difference among the groups for liver lesions such as lobular activity (P=0.007), periportal interface he patitis (P=0.004), portal inflammation (P=0.028) hepatitis with lobular, portal and periportal interface activity (P=0.001). HEV detection by immunohistochemistry was performed and 3 of 6 samples of group 2 were positive. Pigs naturally infected by HEV genotype 3 present microscopic necroinflammatory liver lesions similar to HEV in humans. Liver histopathology showed be important in the diagnosis of active asymptomatic HEV infection in pigs slaughtered for human consumption because hepatic liver lesions may present distinct profiles according to molecular and serological diagnosis and in this sense, histopathology and immunohistochemistry may be an important complementary diagnostic tool.  aHepatitis  aHepatitis E virus  aHistopathology  aImmunohistochemistry  aLiver  aSwine  aZoonoses  aDoença  aHistopatologia  aSuíno  aZoonose  aGenotype 3  aImunohistoquímica  aPathology1 aMALHEIROS, A. P.1 aSOARES, M. do C. P.1 aGOMES-GOUVÊA, M. S.1 aPINHO, J. R. R.1 aPEREIRA, W. L. A.1 aSÁ, L. R. M.  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 38, n. 1, p. 65-70, janeiro 2018.