01053naa a2200181 a 450000100080000000500110000800800410001910000170006024500940007726000090017152004940018065000100067470000160068470000160070070000140071670000180073077301230074820884462018-03-02 2002 bl uuuu u00u1 u #d1 aSORENSEN, A. aLactation induces hypoleptinaemia and activates orexigenic hypothalamic pathways in sheep c2002 aLactation induced a state of negative energy balance and hypoleptinaemia despite food being available ad. libitum. The hypoleptinaemia may be responsible for activating the orexigenic NPY pathway, and decreasing activity of the anorexic melanocortin and CART pathways resulting in hyperphagia during early lactation in sheep. Despite this increased orexigenic drive, the sheep remained in negative energy balance. The reason for sheep continuing in negative energy is still to be resolved. aSheep1 aADAM, C. L.1 aFINDLAY, P.1 aMARIE, M.1 aVERNON, R. G. tIn: ANNUAL MEETING OF THE BRITISH SOCIETY OF ANIMAL SCIENCE, 2002, York. Proceedings... Medlothian: BSAS, 2002. p. 46.