01718naa a2200277 a 450000100080000000500110000800800410001910000160006024501270007626000090020352009180021265000310113065000170116165000110117865000240118965000170121365300140123070000180124470000180126270000190128070000220129970000190132170000170134070000130135777300700137020879802018-02-21       2016    bl uuuu     u00u1 u    #d1 aBIGI, M. M.  aPolymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.h[electronic resource]  c2016  aMycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over&gt99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.  aMycobacterium tuberculosis  aPolymorphism  aAnoxia  aMycobacterium Bovis  aPolimorfismo  aRegulator1 aBLANCO, F. C.1 aARAUJO, F. R.1 aTHACKER, T. C.1 aZUMÁRRAGA, M. J.1 aCATALDI, A. A.1 aSORIA, M. A.1 aBIGI, F.  tMicrobiology and Immunologygv. 60, n. 8, p. 552-560, August 2016