01922naa a2200229 a 450000100080000000500110000800800410001902400490006010000170010924501360012626000090026252012260027165000140149765000190151165000100153065000170154065000160155765300190157365300210159270000170161377300620163020871592018-02-06       1975    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.2527/jas1975.411172x2DOI1 aDAVIS, S. L.  aDose-response influence of prostaglandin E and somatostatin on plasma levels of growth hormone. Prolactin and thyrotropin in sheep.  c1975  aAbstract: Ten ewe lambs (approximately 40 kg) were used to determine the influence of prostaglandin E 1 (PGE1) and synthetic somatotropin-release inhibiting factor (SRIF) on plasma levels of ovine growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). Intravenous injection of PGE1 (20 and 100/ag/kg) stimulated a dose-related increase in plasma levels of GH (20 + 6 and 50 + 10 ng/ml), respectively. Intravenous injection of SRIF (500 ~g), significantly (P&lt.05) depressed the GH stimulation by PGE 1 (20/2g/kg), while lower doses (5 and 50 /lg) were ineffective. The highest dose of PGE 1 (100/2g/kg) also stimulated a significant (P&lt.01) increase in plasma levels of PRL. One and 10/~g doses of PGE1/kg had no influence, while the 20 #g/kg dose appeared to stimulate PRL secretion although the response was quite variable. Treatment with SRIF (500 ~tg) significantly (P&lt.05) reduced the PRL stimulation by PGEI at 20 /.tg/kg. However the variable PRL response to the 20/2g/kg dose of PGE 1 makes this observation inconclusive. Neither PGE 1 nor SRIF exerted an influence on plasma TSH. These data demonstrate the dose-related stimulatory effect of intravenously administered PGE 1 on secretion of GH and PRL.  aProlactin  aProstaglandins  aSheep  aSomatostatin  aThyrotropin  aGrowth hormone  aProstaglandin E11 aANFINSON, M.  tJournal of Animal Sciencegv. 41, n. 1, p. 172?177, 1975.