02905naa a2200289 a 450000100080000000500110000800800410001910000240006024501780008426000090026250001560027152018790042765000090230665000080231565000150232365000220233865300210236065300180238165300140239970000150241370000160242870000200244470000190246470000180248370000170250177300970251820868432018-01-31       2017    bl uuuu     u00u1 u    #d1 aFERNANDES, C. P. M.  aA randomized, double-blind, placebo-controlled study to assess the effect of an aqueous extract of Triticum aestivum on canine outer ear inflammation.h[electronic resource]  c2017  aTítulo em português: Ensaio clínico, randomizado, duplo cego, para tratamento experimental de otite externa com extrato aquoso de Triticum aestivum.  aOuter ear otitis is a multifactorial acute or chronic inflammation of the ear canal, and treatment is often hampered by growing antibiotic resistance. Pre-clinical assessments have shown that an aqueous extract of Triticum aestiveum (wheat) can effectively reduce the symptoms associated with the disease. The purpose of this study was to assess, through a randomized, double-blind, placebo-controlled trial, the use of T. aestivum extract on canine external otitis. Thirty dogs (60 ears) met the criteria to be included in this study, and were randomly assigned a treatment group: placebo, extract, or positive control (C+). Ears were treated every day for seven days, and assessed before treatment (day zero), after treatment (day 7), and again on reassessment (day 14). Clinical assessment included: type of otitis; pinna conformation; presence or absence of itchiness, foul odor, and pain; presence of stenosis, erythema and cerumen. Furthermore, the evaluators assessed the temperature in each ear and the pH of the cerumen, and swabs were collected for bacterial and fungal isolation. All veterinarians treating and assessing the animals were blinded regarding the treatment groups. Results showed little difference in the treatment groups regarding clinical parameters. By day 7 ears treated with the C+ had elevated temperatures, when compared to the others (P&lt0.05), this was still true on day 14. Bacterial isolation had completely died out by day 7, however, on day fourteen the placebo group had six ears with bacterial infections, unlike the other two groups (P&lt0.05). The results generated herein show that a 25% wheat extract solution is effective in the reduction of clinical and microbiological parameters of external otitis, with better results when compared to a placebo, and similar results to the traditional, antibiotic/anti-inflammatory treatment.  aDogs  aCao  aTratamento  aTriticum Aestivum  aEar inflammation  aOtite externa  aTreatment1 aHIJANO, A.1 aLIMA, C. S.1 aFONTOURA, E. G.1 aSCHRAMM, R. C.1 aFÉLIX, S. R.1 aNOBRE, M. O.  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 37, n. 11, p. 1270-1274, novembro 2017.