02267naa a2200325 a 450000100080000000500110000800800410001910000200006024500930008026000090017350000830018252012650026565000270153065000110155765000200156865000160158865000120160465000140161665000190163065300350164965300300168465300210171465300220173570000160175770000190177370000160179270000200180870000180182877300950184620810132017-12-29       2017    bl uuuu     u00u1 u    #d1 aBASSUINO, D. M.  aSpontaneous poisoning by Sida carpinifolia (Malvaceae) in horses.h[electronic resource]  c2017  aTítulo em português: Intoxicação natural por Sida carpinifolia em equinos.  aSida carpinifolia poisoning causes a chronic neurodegenerative disorder associated with lysosomal storage by indolizidine alkaloids (swainsonine). The epidemiological, clinical, pathological and lectin histochemistry findings of an outbreak of natural poisoning by S. carpinifolia in horses in Rio Grande do Sul state, Brazil, are described. Five horses from a total of 15 that were kept on native pasture with large amounts of S. carpinifolia presented during 90 days clinical signs of progressive weight loss, incoordination, stiff gait and ramble, in addition to exacerbated reactions and locomotion difficulty after induced movement. Four horses died, and one of them was submitted for necropsy. At necropsy, no significant gross lesions were observed. Histological findings observed in the central nervous system were characterized by swollen neurons with cytoplasm containing multiple microvacuoles; these abnormalities were more severe in the thalamus, hippocampus, cerebellum and pons. Using lectin histochemistry, the pons and hippocampus sections stained positive for commercial lectin Con-A, sWGA and WGA. This study aimed to detail S. carpinifolia poisoning in horses to be included in the differential diagnoses of neurological diseases of horses.  aCentral nervous system  aHorses  aPlant poisoning  aSwainsonine  aEqüino  aMalvaceae  aPlanta tóxica  aDoença do acúmulo lisossomal  aLysosomal storage disease  aPoisoning plants  aSida carpinifolia1 aKONRADT, G.1 aBIANCHI, M. V.1 aREIS, M. O.1 aPAVARINI, S. P.1 aDRIEMEIER, D.  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 37, n. 9, p. 926-930, setembro. 2017.