02243naa a2200277 a 450000100080000000500110000800800410001902400590006010000200011924501410013926000090028052012690028965000210155865300230157965300260160265300380162865300360166665300320170265300220173465300370175665300200179370000180181370000210183170000230185277300900187520775042017-10-17       2014    bl uuuu     u00u1 u    #d7 ahttp://dx.doi.org/10.1590/S0100-736X20140002000062DOI1 aROJAS, T. C. G.  aIn silico phylogenetic and virulence gene profile analyses of avian pathogenic Escherichia coli genome sequences.h[electronic resource]  c2014  aAvian pathogenic Escherichia coli (APEC) infections are responsible for significant losses in the poultry industry worldwide. A zoonotic risk has been attributed to APEC strains because they present similarities to extraintestinal pathogenic E. coli (ExPEC) associated with illness in humans, mainly urinary tract infections and neonatal meningitis. Here, we present in silico analyses with pathogenic E. coli genome sequences, including recently available APEC genomes. The phylogenetic tree, based on multi-locus sequence typing (MLST) of seven housekeeping genes, revealed high diversity in the allelic composition. Nevertheless, despite this diversity, the phylogenetic tree was able to cluster the different pathotypes together. An in silico virulence gene profile was also determined for each of these strains, through the presence or absence of 83 well-known virulence genes/traits described in pathogenic E. coli strains. The MLST phylogeny and the virulence gene profiles demonstrated a certain genetic similarity between Brazilian APEC strains, APEC isolated in the United States, UPEC (uropathogenic E. coli) and diarrheagenic strains isolated from humans. This correlation corroborates and reinforces the zoonotic potential hypothesis proposed to APEC.  aEscherichia Coli  aAnálise in silico  aÁrvore filogenética  aAvian pathogenic Escherichia coli  aGenes associados à virulência  aMulti-locus Sequence Typing  aPhylogenetic tree  aTipagem de sequência multilocus  aVirulence genes1 aMALUTA, R. P.1 aKOENIGKAN, L. V.1 aSILVEIRA, W. D. da  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 34, n. 2, p. 129-133, fev. 2014.