02498naa a2200373 a 450000100080000000500110000800800410001902400270006010000190008724501420010626000090024852014130025765000160167065000200168665000200170665000120172665000180173865300360175665300290179270000200182170000230184170000200186470000200188470000160190470000170192070000180193770000200195570000190197570000180199470000230201270000180203570000260205377300450207920734822019-06-14       2016    bl uuuu     u00u1 u    #d7 a10.1038/srep394932DOI1 aTIZIOTO, P. L.  aGene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake.h[electronic resource]  c2016  aResidual feed intake (RFI), a measure of feed efficiency (FE), is defined as the difference between the observed and the predictable feed intake considering size and growth of the animal. It is extremely important to beef production systems due to its impact on the allocation of land areas to alternative agricultural production, animal methane emissions, food demand and cost of production. Global differential gene expression analysis between high and low RFI groups (HRFI and LRFI: less and more efficient, respectively) revealed 73 differentially expressed (DE) annotated genes in Longissimus thoracis (LT) muscle of Nelore steers. These genes are involved in the overrepresented pathways Metabolism of Xenobiotics by Cytochrome P450 and Butanoate and Tryptophan Metabolism. Among the DE transcripts were several proteins related to mitochondrial function and the metabolism of lipids. Our findings indicate that observed gene expression differences are primarily related to metabolic processes underlying oxidative stress. Genes involved in the metabolism of xenobiotics and antioxidant mechanisms were primarily down-regulated, while genes responsible for lipid oxidation and ketogenesis were up-regulated in HRFI group. By using LT muscle, this study reinforces our previous findings using liver tissue and reveals new genes and likely tissue-specific regulators playing key-roles in these processes.  aBeef cattle  aFeed conversion  aGene expression  aNellore  aGado de corte  aGenome-wide association studies  aQuantitative trait locus1 aCOUTINHO, L. L.1 aOLIVEIRA, P. S. N.1 aCESAR, A. S. M.1 aDINIZ, W. J. S.1 aLIMA, A. O.1 aROCHA, M. I.1 aDECKER, J. E.1 aSCHNABEL, R. D.1 aMOURÃO, G. B.1 aTULLIO, R. R.1 aZERLOTINI NETO, A.1 aTAYLOR, J. F.1 aREGITANO, L. C. de A.  tScientific Reportsgv. 6, p. 1-12, 2016.