02996naa a2200373 a 450000100080000000500110000800800410001902400270006010000240008724501360011126000090024750000380025652018670029465000150216165000180217665000200219465000090221465300230222365300260224665300150227265300170228770000170230470000180232170000270233970000230236670000210238970000230241070000200243370000240245370000190247770000180249670000210251477300870253520648942023-01-30       2017    bl uuuu     u00u1 u    #d7 a10.1111/jpn.125722DOI1 aGIONBELLI, T. R. S.  aIntestinal development of bovine foetuses during gestation is affected by foetal sex and maternal nutrition.h[electronic resource]  c2017  aPublicado online em 16 ago. 2016.  aSummary We aimed to evaluate the effects of maternal nutrition (MN) and foetal sex on the intestinal development ofbovine foetuses throughout different days of gestation (DG). Forty-four multiparous, dry Holstein 9 Gyr cowswith average initial body weight of 480 +/_ 10 kg were fed the same diet of either restricted feeding at 1.15% ofbody weight (CO, n = 24) or fed ad libitum (overnourished, ON, n = 20). Six cows from CO group and five cowsfrom ON group were slaughtered at 139, 199, 241 and 268 DG, and foetuses were necropsied to evaluate theintestinal development. The mass, length and density of foetal intestines were not affected by MN (p ≥ 0.260).An interaction between MN and DG was observed for the villi length of jejunum (p = 0.006) and ileum(p &lt 0.001). Villi length of jejunum and ileum was higher (p &lt 0.10) in foetuses from ON-fed cows than in foe-tuses from CO-fed cows at 139 DG. However, at 199 DG, the villi length of jejunum and ileum of foetuses fromCO-fed cows was higher than in foetuses from ON-fed cows. Despite these differences, MN did not affect the villilength of jejunum and ileum at 268 DG (p &gt 0.10). Female foetuses had greater small intestine mass (p = 0.093),large intestine mass (p = 0.022), small intestine mass in proportion to body mass (p = 0.017) and large intestinemass in proportion to body mass (p &lt 0.001) than male foetuses. Female foetuses had also longer small intestine(p = 0.077) and greater small intestine density (p = 0.021) and villi length of jejunum (p = 0.001) and ileum(p = 0.010) than males. We conclude that MN affects the pathway for the development of foetal villi lengththroughout the gestation in bovine foetuses without changing the final villi length. Female foetuses had higherintestinal mass, density and villi length than males during the foetal phase in bovines.  aabsorption  afeeding level  asmall intestine  azebu  aFoetal programming  aIntestinal morphology  aSex-biased  aVilli length1 aROTTA, P. P.1 aVELOSO, C. M.1 aVALADARES FILHO, S. C.1 aCARVALHO, B. C. de1 aMARCONDES, M. I.1 aFERREIRA, M. F. L.1 aSOUZA, J. V. F.1 aSANTOS, J. S. A. A.1 aLACERDA, L. C.1 aDUARTE, M. S.1 aGIONBELLI, M. P.  tJournal of Animal Physiology and Animal Nutritiongv. 101, n. 3, p. 493-501, 2017.