02645naa a2200265 a 450000100080000000500110000800800410001902400390006010000180009924501580011726000090027552018370028465000190212165000100214065000150215065000220216570000180218770000200220570000220222570000170224770000170226470000160228170000220229777300600231920626842017-02-03       2016    bl uuuu     u00u1 u    #d7 a10.1016/j.insoeop.2016.09.0282DOI1 aPERIGO, C. V.  aThe chemical composition and antibacterial activity of eleven Piper species from distinct rainforest areas in Southeastern Brazil.h[electronic resource]  c2016  aPiper is a large and highly diverse genus of plants with medicinal and aromatic use. Itis widely distributed in tropical forests occupying distinct environments. We have determined the chemical composition ofthe essential oils from 11 species of Piper from seven locations of Atlantic rainforestin Brazil. The essential oils were isolated by hydrodistillation and their composition, determined by GC?MS. The chemical composition of the oils exhibits qualitative and quantitative differences among the species and intraspecifically for distinct locations. Mono and sesquiterpenes were the most abundant compounds, although P. aduncum also contained phenylpropanoids. The oils of P. xylosteoides, P. umbellatum and P. leptorum from coastal and inland regions consisted exclusively of oxygenated sesquiterpenes. In contrast, monoterpene was the sole chemical class in the oils extracted from P. rivinoides and P. solmsianum. Hierarchical clustering analyses demonstrated the chemical phenotype is associated to species-specific and environmental factors. The essential oils from the majority of the investigated Piper species exhibit inhibitory activity against pathogenic bacteria in vitro, reaching up to 30% of the inhibition levels of commercial antibiotics. The contents of bicyclogermacre and -muurolene were positively associated to E. coli inhibition, whereas, levels of germacrene D and trans-caryophyllene were associated to the inhibitory activity against all tested bacteria. Limonene and cis--ocymene were associated with Staphylococci inhibition. Higher contents of -phellandrene were positively correlated to wide spectrum antibacterial activity. Taken together, our results demonstrate the chemical diversity of Piper essential oils and their potential as novel antibacterial agents for several industrial applications.  aEssential oils  aPiper  aPiperaceae  aPlanta aromática1 aTORRES, R. B.1 aBERNACCI, L. C.1 aGUIMARÃES, E. F.1 aHABER, L. L.1 aFACANALI, R.1 aQUECINI, V.1 aMARQUES, M. O. M.  tIndustrial Crops and Productsgv. 94, p. 528-539, 2016.