01520nam a2200289 a 450000100080000000500110000800800410001910000170006024501340007726001980021130000190040952005460042865000190097465000230099365000230101665300200103965300130105965300090107270000190108170000230110070000170112370000220114070000180116270000160118070000200119670000140121620622142020-01-07       2016    bl uuuu     u00u1 u    #d1 aFULAZ, S. F.  aDesign of inhibitors for the PilT protein from Xylella fastidiosa using in silico and in vitro approaches.h[electronic resource]  aIn: ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 45., 2016, Natal. Livro de resumos... [Natal]: Sociedade Brasileira de Bioquímica e Biologia Molecularc2016  aNão paginado.  aXylella fastidiosa (Xf) is a Gram-negative xylem-limited bacterium responsible for diseases (in approximately 200 hosts) such as Pierce?s disease (grapevines-EUA), citrus variegated chlorosis (Brazil) and leaf scorch diseases (olive tree-Italy). The type IV pili has an important role in the bacteria pathogenicity, since it is responsible for the motility and dispersion in surfaces, auto aggregation and biofilm formation. Commonly, the energy required for this movement is provided by ATP hydrolysis promoted by PilB and/or PilT proteins.  aBioinformatics  aBiologia molecular  aXylella Fastidiosa  aBioinformática  aInibidor  aPilT1 aCABRINI, F. M.1 aCARVALHO, D. J. P.1 aBORRO, L. C.1 aSANTOS, C. A. dos1 aBELOTI, L. L.1 aNESHICH, G.1 aSOUZA, A. P. de1 aTASIC, L.