02148naa a2200337 a 450000100080000000500110000800800410001902400270006010000190008724501350010626000090024130000150025049000070026552012140027265000120148665000160149865000160151465300230153065300100155365300230156365300080158670000200159470000170161470000220163170000230165370000180167670000170169470000180171170000260172977300550175520551572018-11-07       2016    bl uuuu     u00u1 u    #d7 a10.1111/age.124322DOI1 aTIZIOTO, P. C.  aVariation in myogenic differentiation 1 mRNA abundance is associated with beef tenderness in Nelore cattle.h[electronic resource]  c2016  a491-494 47  v47  aThe myogenic differentiation 1 gene (MYOD1) has a key role in skeletal muscle differentiation and composition through its regulation of the expression of several muscle-specific genes. We first used a general linear mixed model approach to evaluate the association of MYOD1 expression levels on individual beef tenderness phenotypes. MYOD1 mRNA levels measured by quantitative polymerase chain reactions in 136 Nelore steers were significantly associated (P ? 0.01) with Warner?Bratzler shear force, measured on the longissimus dorsi muscle after 7 and 14 days of beef aging. Transcript abundance for the muscle regulatory gene MYOD1 was lower in animals with more tender beef. We also performed a coexpression network analysis using whole transcriptome sequence data generated from 30 samples of longissimus muscle tissue to identify genes that are potentially regulated by MYOD1. The effect of MYOD1 gene expression on beef tenderness may emerge from its function as an activator of muscle-specific gene transcription such as for the serum response factor (C-fos serum response element-binding transcription factor) gene (SRF), which determines muscle tissue development, composition, growth and maturation.  aNellore  aBos Indicus  aGado Nelore  aExpressão gênica  aMYOD1  aQualidade da carne  aSRF1 aCOUTINHO, L. L.1 aGASPARIN, G.1 aMALAGO JUNIOR, W.1 aDONATONI, F. A. B.1 aTULLIO, R. R.1 aNASSU, R. T.1 aTAYLOR, J. F.1 aREGITANO, L. C. de A.  tAnimal Geneticsgv.47, n.4, p. 491-494, aug. 2016.