01567naa a2200217 a 450000100080000000500110000800800410001910000180006024501350007826000090021352009460022265000090116865000150117765000150119265300140120765300160122165300140123765300230125170000210127477300540129510104892016-02-17       1985    bl uuuu     u00u1 u    #d1 aFAGGIN, B. M.  aDifferential alterations in brain sensivity to amphetamine and pentylenetetrazol in socially deprived mice.h[electronic resource]  c1985  aMice deprived of social interactions for different periods of time (56, 69, 79, 89 or 97 days) were studied. Social isolation increased both general activity observed in an open-field and amphetamine-induced hyperactivity; CNS responsiveness to pentylenetetrazol-induced convulsions; however, decreased. The differences in general activity were detected after 69 and 79 days of social deprivation; the hyperactivity induced by amphetamine was greater after 79 days of isolation and the pentylenetetrazol CD50s were higher after 56, 69 and 79 days solitude. These data, obtained with mice, show first that isolation time is an important variable to display drug effects and secondly that long-term deprivation of social stimuli does not increase CNS susceptibility to all stimulant drugs. A combination of a higher release of catecholamines onto previously supersensitive receptors was considered to be involved with the differences observed.  amice  aCamundongo  aIsolamento  aAtividade  aEstimulante  aIsolation  aStimulant activity1 aPALERMO NETO, J.  tGeneral Pharmacologygv.16, n.3, p.299-302, 1985.