02534naa a2200325 a 450000100080000000500110000800800410001902400550006010000270011524501240014226000090026652015330027565000200180865000230182865000200185165000210187165000250189265300200191765300250193770000200196270000230198270000190200570000230202470000190204770000210206670000140208770000170210170000180211877300720213620453102016-06-09       2015    bl uuuu     u00u1 u    #d7 ahttp://dx.doi.org/10.4238/2015.December.21.272DOI1 aRAGOGNETTI, B. do N. N  aGenetic parameters and mapping quantitative trait loci associated with tibia traits in broilers.h[electronic resource]  c2015  aAbstract: Selection among broilers for performance traits is resulting in locomotion problems and bone disorders, once skeletal structure is not strong enough to support body weight in broilers with high growth rates. In this study, genetic parameters were estimated for body weight at 42 days of age (BW42), and tibia traits (length, width, and weight) in a population of broiler chickens. Quantitative trait loci (QTL) were identified for tibia traits to expand our knowledge of the genetic architecture of the broiler population. Genetic correlations ranged from 0.56 +/- 0.18 (between tibia length and BW42) to 0.89 +/- 0.06 (between tibia width and weight), suggesting that these traits are either controlled by pleiotropic genes or by genes that are in linkage disequilibrium. For QTL mapping, the genome was scanned with 127 microsatellites, representing a coverage of 2630 cM. Eight QTL were mapped on Gallus gallus chromosomes (GGA): GGA1, GGA4, GGA6, GGA13, and GGA24. The QTL regions for tibia length and weight were mapped on GGA1, between LEI0079 and MCW145 markers. The gene DACH1 is located in this region; this gene acts to form the apical ectodermal ridge, responsible for limb development. Body weight at 42 days of age was included in the model as a covariate for selection effect of bone traits. Two QTL were found for tibia weight on GGA2 and GGA4, and one for tibia width on GGA3. Information originating from these QTL will assist in the search for candidate genes for these bone traits in future studies.  aAnimal genetics  aMolecular genetics  aFrango de corte  aGenética animal  aParâmetro genético  aBroiler chicken  aMapeamento genético1 aSTAFUZZA, N. B.1 aSILVA, T. B. R. da1 aCHUD, T. C. S.1 aGRUPIONI, V. A. R.1 aCRUZ, V. A. R.1 aDANTAS, J. de O.1 aNONES, K.1 aLEDUR, M. C.1 aMUNARI, D. P.  tGenetics and Molecular Researchgv. 14, n. 4, p. 17544-17554, 2015.