02061naa a2200265 a 450000100080000000500110000800800410001902400350006010000250009524501240012026000090024452011820025365300300143565300250146565300270149070000230151770000230154070000220156370000210158570000220160670000280162870000280165670000250168477300860170920156702022-05-31       2015    bl uuuu     u00u1 u    #d7 a10.1007/s10973-014-4380-42DOI1 aSANCHES, S. C. da C.  aThermal characterization study of chondroitin sulfate-co-N-isopropylacrylamide as drugs carrier.h[electronic resource]  c2015  aPoly(N-isopropylacrylamide) (PNIPAAm) is formed by polymerization of the monomer N-isopropylacrylamide (NIPAAm) and is classified as thermosensitive due to its ability to expand and contract at a certain temperature. Chondroitin sulfate is called bioadhesive as it increases the permanence time of the drug in the body, enhancing its bioavailability. In this study, the copolymer chondroitin sulfate-co-N-isopropylacrylamide (CSM) is proposed as a new drug carrier and thermal analysis is used to choose among the copolymers CSM + NIPAAm 5 % (w/v), CSM + NIPAAm 2.5 % (w/v) and CSM + PNIPAAm 2.5 % (w/v), the one with best thermal properties. Proton nuclear magnetic resonance spectroscopy showed structural similarity between the copolymers. Thermogravimetric analysis/derivative thermogravimetry showed that the copolymer CSM + NIPAAm 5 % (w/v) has higher thermal stability when compared to the others. Differential thermal analysis showed thermal values consistent with the events of decomposition while kinetics of degradation confirmed its thermal stability. So the copolymer CSM + NIPAAm 5 % (w/v) presented the best thermal characteristics for an efficient drug carrier.  aCaracterização térmica  aChondroitin sulphate  aSulfato de condroitina1 aVASCONCELOS, F. de1 aCOSTA, C. E. F. da1 aMARINHO, P. S. B.1 aGUILHERME, M. R.1 aTAVARES, E. J. M.1 aDINIZ JÚNIOR, J. A. P.1 aSILVA JÚNIOR, J. O. C.1 aRIBEIRO-COSTA, R. M.  tJournal of Thermal Analysis and Calorimetrygv. 120, n. 1, p. 991-999, Apr. 2015.