01759naa a2200409 a 450000100080000000500110000800800410001902400380006010000160009824501820011426000090029630000280030549000160033352002820034965000220063165300240065365300280067765300240070565300280072965300280075765300230078565300280080865300330083665300290086965300350089865300230093365300300095670000220098670000150100870000170102370000140104070000160105470000150107070000190108570000160110477302290112020082272020-01-08       2015    bl uuuu     u00u1 u    #d7 a10.1007/978-3-319-12211-3_122DOI1 aNESHICH, G.  aUsing structural and physical-chemical parameters to identify, classify, and predict functional districts in proteins-the role of electrostatic potential.h[electronic resource]  c2015  ap. 227-254. Chapter 12.  vChapter 12.  aIn this chapter, we will overview the role of the local protein structure environment (which we will call here: nano-environment) in maintaining the functional purpose of different protein districts (defined as protein structure sites delimited by their functional objectives).  aProtein structure  aBase de dados Sting  aCatalytic site residues  aEfeito hidrofóbico  aElectrostatic potential  aEstrutura de proteínas  aHydrophobic effect  aInterface de proteínas  aPhysical-chemical properties  aPotencial eletrostático  aPropriedades físico-químicas  aProtein interfaces  aSuperfície de proteínas1 aNESHICH, I. A. P.1 aMORAES, F.1 aSALIM, J. A.1 aBORRO, L.1 aYANO, I. H.1 aMAZONI, I.1 aJARDINE, J. G.1 aROCCHIA, W.  tIn: ROCCHIA, W.; SPAGNUOLO, M. (Ed.). Computational electrostatics for biological applications: geometric and numerical approaches to the description of electrostatic interaction between macromolecules. Cham: Springer, 2015.