01942naa a2200289 a 450000100080000000500110000800800410001902400390006010000180009924501440011726000090026152010650027065300190133565300170135465300280137165300230139965300190142265300140144165300130145570000190146870000180148770000180150570000210152370000230154470000220156777300630158920049332017-06-22       2014    bl uuuu     u00u1 u    #d7 aDOI 10.1007/s13233-014-2176-92DOI1 aBRITTO, D. de  aEntrapment characteristics of hydrosoluble vitamins loaded into chitosan and N,N,N-Trimethyl chitosan nanoparticles.h[electronic resource]  c2014  aNanoencapsulation is a process suitable for use in reducing degradation of instable components. In this study, chitosan and trimethyl chitosan with tripolyphosphate were used to nanoencapsulate vitamins C, B9, and B12. Analysis of the particle size showed that for a fix proportion of the polymer tripolyphosphate, the system showed a wide variation in size with the amount of added vitamins: e.g., for vitamin B9, the particle size varied from 150±5 nm to 809±150 nm. The zeta potential confirmed that trimethyl chitosan nanoparticles generally had a lower net positive charge (20 mV) than chitosan nanoparticles (40 mV). The encapsulation efficiency was found to be dependent on nanoparticle structure and vitamin solubility, with vitamin B9 the most efficiently encapsulated (approximately 40%). UV-Visible spectroscopy indicated different release profiles for vitamins C, B9, and B12 in a neutral PBS solution with release rates of 36%, 52%, and 16% after 2, 24, and 4 h, respectively. In conclusion the liberation was found to be slower in acidic media.  aEncapsulamento  aFishery diet  aLibertação controlada  aNanoencapsulação  aNanotecnologia  aQuitosana  aTrimetil1 aMOURA, M. R de1 aAOUADA, F. A.1 aPINOLA, F. G.1 aLUNDSTEDT, L. M.1 aASSIS, O. B. G. de1 aMATTOSO, L. H. C.  tMacromolecular Researchgv. 22, n. 12, p. 1261-1267, 2014.